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Table 1 Experimental vaccine trials using a variety of antigen-preparation methods and their protection in fish following experimental infection

From: Yersinia ruckeri, the causative agent of enteric redmouth disease in fish

Antigens Routes Fish species Challenge strains RPS (%) References
Formalin inactivated high pH Y. ruckeri O1, strain Y-11 Immersion Rainbow trout Y. ruckeri O1, strain Y-12 83–96 [89]
Yrp1 protease toxoid of Y. ruckeri, strain 150RI4 i.p. Rainbow trout Y. ruckeri, strain 150 79 [46]
Live attenuated Y. ruckeri O1, strain 21102 i.p. Rainbow trout Y. ruckeri O1, strain 21102 90 [94]
Formalin inactivated Y. ruckeri O1, biotype 1 Bath Rainbow trout Y. ruckeri O1, strain 392/2003 75–76.9 [61]
Extracellular product of Y. ruckeri Immersion Rainbow trout Y. ruckeri 74–81.4 [95]
Formalin inactivated Y. ruckeri O1b biotype 1 (Yersinivac-B) Immersion Atlantic salmon Y. ruckeri O1b, strain TCFB 2282 37 [91]
Trypsinated Yersinivac-B Immersion Atlantic salmon Y. ruckeri O1b, strain TCFB 2282 55.6 [91]
Formalin inactivated Y. ruckeri serotype O1, biotype 1 × biotype 2 (EX5) Immersion Rainbow trout Y. ruckeri O1, strains EX5, 58669, G1S1, DenA, BAS2A 87–100 [16]
Formalin inactivated Y. ruckeri serotype O1, biotype 1 × biotype 2 (EX5) Immersion and i.p. Rainbow trout Y. ruckeri O1, biotype 2, strain 100415-1/4 100 [97]
Formalin inactivated Y. ruckeri biotype 1, strain Hagerman Immersion Rainbow trout Y. ruckeri O1, biotype 2, strain 100415-1/4 29.5 [64]
Recombinant flagellin protein of Y. ruckeri biotype 1 BA19 i.p. Rainbow trout Y. ruckeri biotype 1 YR1 and biotype 2 R1 68–72 [99]
Formalin inactivated Y. ruckeri biotype 1, strain KC291153 Immersion with montanide adjuvant Rainbow trout Y. ruckeri biotype 1, strain KC291153 93.8–100 [82]
Lipopolysaccharide of Y. ruckeri i.p. Rainbow trout Y. ruckeri 77.4–85.1 [94]
Formalin inactivated Y. ruckeri biotype 1, strain Hagerman Oral and anal Rainbow trout Y. ruckeri O1, biotype 1, strain 392 100 [93]
  1. i.pc intraperitoneal injection, RPS relative percentage survival.