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Table 1 Experimental vaccine trials using a variety of antigen-preparation methods and their protection in fish following experimental infection

From: Yersinia ruckeri, the causative agent of enteric redmouth disease in fish

Antigens

Routes

Fish species

Challenge strains

RPS (%)

References

Formalin inactivated high pH Y. ruckeri O1, strain Y-11

Immersion

Rainbow trout

Y. ruckeri O1, strain Y-12

83–96

[89]

Yrp1 protease toxoid of Y. ruckeri, strain 150RI4

i.p.

Rainbow trout

Y. ruckeri, strain 150

79

[46]

Live attenuated Y. ruckeri O1, strain 21102

i.p.

Rainbow trout

Y. ruckeri O1, strain 21102

90

[94]

Formalin inactivated Y. ruckeri O1, biotype 1

Bath

Rainbow trout

Y. ruckeri O1, strain 392/2003

75–76.9

[61]

Extracellular product of Y. ruckeri

Immersion

Rainbow trout

Y. ruckeri

74–81.4

[95]

Formalin inactivated Y. ruckeri O1b biotype 1 (Yersinivac-B)

Immersion

Atlantic salmon

Y. ruckeri O1b, strain TCFB 2282

37

[91]

Trypsinated Yersinivac-B

Immersion

Atlantic salmon

Y. ruckeri O1b, strain TCFB 2282

55.6

[91]

Formalin inactivated Y. ruckeri serotype O1, biotype 1 × biotype 2 (EX5)

Immersion

Rainbow trout

Y. ruckeri O1, strains EX5, 58669, G1S1, DenA, BAS2A

87–100

[16]

Formalin inactivated Y. ruckeri serotype O1, biotype 1 × biotype 2 (EX5)

Immersion and i.p.

Rainbow trout

Y. ruckeri O1, biotype 2, strain 100415-1/4

100

[97]

Formalin inactivated Y. ruckeri biotype 1, strain Hagerman

Immersion

Rainbow trout

Y. ruckeri O1, biotype 2, strain 100415-1/4

29.5

[64]

Recombinant flagellin protein of Y. ruckeri biotype 1 BA19

i.p.

Rainbow trout

Y. ruckeri biotype 1 YR1 and biotype 2 R1

68–72

[99]

Formalin inactivated Y. ruckeri biotype 1, strain KC291153

Immersion with montanide adjuvant

Rainbow trout

Y. ruckeri biotype 1, strain KC291153

93.8–100

[82]

Lipopolysaccharide of Y. ruckeri

i.p.

Rainbow trout

Y. ruckeri

77.4–85.1

[94]

Formalin inactivated Y. ruckeri biotype 1, strain Hagerman

Oral and anal

Rainbow trout

Y. ruckeri O1, biotype 1, strain 392

100

[93]

  1. i.pc intraperitoneal injection, RPS relative percentage survival.