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Table 1 Transmission of L-BSE isolates to micea

From: Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice

Hosts

Source

Inoculum

Passage

Survival periods (days)b

Range (days)

Proportion of PrPSc micec

Brain

Spleen

ICR [14]

L-BSE/cattle [18]

Brain

1

651 ± 153

322–953

0/35

0/35

ICR

L-BSE/cattle passaged in ICR mice

Brain

2

666 ± 198

386–937

0/10

0/10

C57BL/6d

L-BSE/cattle [18]

Brain

1

713 ± 42

673–757

0/5

0/5

ICR

L-BSE/sheep [16]

Brain

1

569 ± 262

172–1012

1/15

9/15

ICR

L-BSE/sheep passaged in ICR mice

Spleen

2

691 ± 61

639–765

6/6

6/6

TgBoPrP

L-BSE/cattle [18]

Brain

1

195 ± 6

187-211

18/18

0/18

TgBoPrP

L-BSE/cattle passaged in TgBoPrP mice

Brain

2

152 ± 2

148-155

24/24

0/24

TgBoPrP

L-BSE/sheep [16]

Brain

1

249 ± 28

234-298

5/5

0/5

TgBoPrP

L-BSE/sheep passaged in TgBoPrP mice

Brain

2

269 ± 17

248-305

13/13

0/13

  1. aTgBoPrP, bovine PrP expressing transgenic; L-BSE, L-type bovine spongiform encephalopathy; PrPSc, disease-associated prion protein.
  2. bmean ± standard deviation.
  3. cNumber of PrPSc positive tissue samples per number of examined tissue samples. Results from either western blot, immunohistochemistry, or both.
  4. dUnpublished data from our laboratory.