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Table 1 Transmission of L-BSE isolates to micea

From: Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice

Hosts Source Inoculum Passage Survival periods (days)b Range (days) Proportion of PrPSc micec
Brain Spleen
ICR [14] L-BSE/cattle [18] Brain 1 651 ± 153 322–953 0/35 0/35
ICR L-BSE/cattle passaged in ICR mice Brain 2 666 ± 198 386–937 0/10 0/10
C57BL/6d L-BSE/cattle [18] Brain 1 713 ± 42 673–757 0/5 0/5
ICR L-BSE/sheep [16] Brain 1 569 ± 262 172–1012 1/15 9/15
ICR L-BSE/sheep passaged in ICR mice Spleen 2 691 ± 61 639–765 6/6 6/6
TgBoPrP L-BSE/cattle [18] Brain 1 195 ± 6 187-211 18/18 0/18
TgBoPrP L-BSE/cattle passaged in TgBoPrP mice Brain 2 152 ± 2 148-155 24/24 0/24
TgBoPrP L-BSE/sheep [16] Brain 1 249 ± 28 234-298 5/5 0/5
TgBoPrP L-BSE/sheep passaged in TgBoPrP mice Brain 2 269 ± 17 248-305 13/13 0/13
  1. aTgBoPrP, bovine PrP expressing transgenic; L-BSE, L-type bovine spongiform encephalopathy; PrPSc, disease-associated prion protein.
  2. bmean ± standard deviation.
  3. cNumber of PrPSc positive tissue samples per number of examined tissue samples. Results from either western blot, immunohistochemistry, or both.
  4. dUnpublished data from our laboratory.