Figure 5

MAP intermittent shedding dynamics with the granuloma model. Simulations with the granuloma model (Equation 4), with parameter values d = 0.04, i = 0.38, ρ = 1, and b = 0.04. (A) The parameter R _MF  = 0 before day 630, between days 810 and 990, and between days 1170–1350, otherwise R _MF  = 1.1. (B) The parameter R _MF  = 0.2 before day 630, between days 810 and 990, and between days 1170–1350, otherwise R _MF  = 1.1. This reflects a cow with yearly calving and higher R _MF three months before and three months after calving.