Figure 4

MAP dynamics with the granuloma model. Simulations with the granuloma model (Equation 4), with parameter values d = 0.04, i = 0.38, ρ = 1, and b = 0.04. Other parameters: (A) T _MAP  = 1.0, R _MF  = 0; (B) T _MAP  = 2.5, R _MF  = 0; (C) T _MAP  = 2.5, R _MF  = 0.2; (D) T _MAP  = 2.5, R _MF  = 1.1. Initial conditions: (M _u , M _i ) = (0, 3) (black curves); (M _u , M _i ) = (0, 2) (dark grey curves) (M _u , M _i ) = (0, 1) (light grey curve).