Neutrophil extracellular traps in sheep mastitis

Pisanu, Salvatore; Cubeddu, Tiziana; Pagnozzi, Daniela; Rocca, Stefano; Cacciotto, Carla; Alberti, Alberto; Marogna, Gavino; Uzzau, Sergio; Addis, Maria Filippa

doi:10.1186/s13567-015-0196-x

Veterinary Research

Table 2 Selected protein function ontology classes including proteins involved in inflammation and immune response processes

From: Neutrophil extracellular traps in sheep mastitis

Accession	Protein functions and names	R_SC
	Defense response
P05164	Myeloperoxidase	5.62
B6E141	Haptoglobin (Zonulin)	4.78
O77774	Neutrophil cytosol factor 1	4.70
P0C0S4	Histone H2A.Z	4.65
P54230	Cathelicidin-1	4.09
P70248	Unconventional myosin-If	3.79
Q00655	Tyrosine-protein kinase SYK	3.64
P50415	Cathelicidin-3	3.57
P06800	Receptor-type tyrosine-protein phosphatase C	3.07
P80190	Lysozyme C, kidney isozyme	3.07
P56425	Cathelicidin-7	2.85
Q2HJ57	Coactosin-like protein	2.48
P79362	Cathelicidin-2	2.46
Q60710	SAM domain and HD domain-containing protein 1	2.35
P17453	Bactericidal permeability-increasing protein	2.33
Q92608	Dedicator of cytokinesis protein 2	2.30
P80025	Lactoperoxidase	1.50
	Immune response
P70248	Unconventional myosin-If	3.79
P15497	Apolipoprotein A-I	2.10
Q29477	Lactotransferrin	4.33
Q00655	Tyrosine-protein kinase SYK	3.64
O46521	Cytochrome b-245 light chain	3.12
Q3UP87	Neutrophil elastase	2.77
Q3MHR7	Actin-related protein 2/3 complex subunit 2	3.39
Q92608	Dedicator of cytokinesis protein 2	2.30
P06800	Receptor-type tyrosine-protein phosphatase C	3.07
Q60710	SAM domain and HD domain-containing protein 1	2.35
P13796	Plastin-2	2.30
P47845	Galectin-3	1.85
P11215	Integrin alpha-M	1.55
	Innate immune response
Q29477	Lactotransferrin	4.33
P70248	Unconventional myosin-If	3.79
Q00655	Tyrosine-protein kinase SYK	3.64
Q3MHR7	Actin-related protein 2/3 complex subunit 2	3.39
O46521	Cytochrome b-245 light chain	3.12
P28783	Protein S100-A9	2.79
P28782	Protein S100-A8	2.65
Q60710	SAM domain and HD domain-containing protein 1	2.35
P47845	Galectin-3	1.85
P11215	Integrin alpha-M	1.55
	Inflammatory response
Q8SPQ0	Chitinase-3-like protein 1	5.09
O77774	Neutrophil cytosol factor 1	4.70
O46521	Cytochrome b-245 light chain	3.12
Q2UVX4	Complement C3	2.85
P28783	Protein S100-A9	2.79
Q3UP87	Neutrophil elastase	2.77
P28782	Protein S100-A8	2.65
P15497	Apolipoprotein A-I	2.10
P98066	Tumor necrosis factor-inducible gene 6 protein	2.08
	Peptidase activity
Q29477	Lactotransferrin	4.33
Q2UVX4	Complement C3	2.85
P28783	Protein S100-A9	2.79
Q3UP87	Neutrophil elastase	2.77
P28782	Protein S100-A8	2.65
P80209	Cathepsin D	2.27
P81286	Plasminogen	2.25
P23004	Cytochrome b-c1 complex subunit 2, mitochondrial	2.18
Q27970	Calpain-1 catalytic subunit	1.85
	Integrin-mediated signaling pathway
Q5VI41	Integrin beta-2	6.53
Q00655	Tyrosine-protein kinase SYK	3.64
P11215	Integrin alpha-M	1.55
	Neutrophil chemotaxis
Q00655	Tyrosine-protein kinase SYK	3.64
P28783	Protein S100-A9	2.79
P28782	Protein S100-A8	2.65
P11215	Integrin alpha-M	1.55
	Acute-phase response
B6E141	Haptoglobin (Zonulin)	4.78
P85521	Scavenger receptor cysteine-rich type 1 protein	2.49
	Protein citrullination
O02849	Protein-arginine deiminase type-3	2.86
Q9UM07	Protein-arginine deiminase type-4	2.38
	Secretory granule
P05164	Myeloperoxidase	5.62
Q3UP87	Neutrophil elastase	2.77

All differences were statistically significant (P < 0.05; Beta-binomial test).

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ISSN: 1297-9716

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