Experimental timeline of events. Experiment timeline from study initiation (Day 0) to termination (Day 78). On Day 0, the seeder pig was orally challenged with PEDV. On Days 1 and 2, 1 and 12 contact pigs, respectively were placed with the seeder pig. On Day 7, the Principle Group (PG) consisting of 9 contact pigs, and the Stationary Group (SG) consisting of 4 contact pigs and the seeder pig were selected. On Days 7, 14, 21, and 28, pigs S1, S2, S3, and S4, were commingled with the PG, respectively. On Days 10, 17, 24, and 31, the respective sentinel pig was removed and placed in a separate room. S1 was euthanized and necropsied on Day 30. All other study animals were euthanized and necropsied on Day 78. At Day 49 naïve pigs (N) and PG received PEDV challenge (PG/C: principal virus reservoir group post-challenge. N/C: naïve pigs post-challenge).