Table 6 Upstream regulators and their biological functions

IL1B (proinflammatory; proliferation; differentiation; apoptosis)

6.80E-23

lipopolysaccharide (increase of TLR4 expression; innate immune response)

8.75E-22

IRAK4 (activation of NF-kB; innate immune response)

6.93E-21

TNF (proinflammat.; proliferation; differentiation; apoptosis; lipid metabolism; coagulation)

1.17E-20

cycloheximide (inhibitor of protein synthesis; apoptosis, cell death)

3.04E-20

3 h  S. aureus- challenged vs. unchallenged control cells

p -value of overlap

beta-estradiol (proliferation; growth; apoptosis; breast cancer signaling)

1.20E-10

ESR1 (growth; proliferation; transcription; transactivation)

2.00E-09

U0126 (inhibitor of MAP kinase kinase; apoptosis; proliferation; migration)

3.74E-09

3-methylcholanthrene (carcinogen; transformation; proliferation)

1.59E-08

paclitaxel (antimitotic; apoptosis; growth; survival; cell viability)

2.55E-08

24 h E. coli- challenged vs. unchallenged control cells

p -value of overlap

PD98059 (inhibitor of MAP kinase kinase; apoptosis; proliferation; migration)

1.98E-11

IKBKB (activation of NF-kB; apoptosis; proliferation)

8.45E-11

TGFB1 (proliferation; differentiation; adhesion; migration; apoptosis; growth)

1.47E-10

RAF1 (activation of MEK1/2; apoptosis; proliferation; differentiation; cell cycle; migration)

1.90E-10

HGF (activation of tyrosine kinases; migration; proliferation; scattering; apoptosis; growth)

9.20E-10

24 h  S. aureus- challenged vs. unchallenged control cells

p -value of overlap

RAF1 (activation of MEK1/2; apoptosis; proliferation; differentiation; cell cycle; migration)

2.30E-09

E2F1 (apoptosis; proliferation; cell cycle)

3.32E-08

TP53 (tumor suppressor; apoptosis; cell cycle; growth; proliferation)

3.45E-07

INSR (proliferation; growth; differentiation; migration; mitogenesis)

9.61E-07

PD98059 (inhibitor of MAP kinase kinase; apoptosis; proliferation; migration)

1.24E-06