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Table 5 Down-regulated canonical pathways in PMEC at 24 hpc

From: Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro

E. coli- challenged vs. unchallenged control cells  
Canonical pathway (Genes involved in pathway) p -value
Estrogen-mediated S-phase Entry(CCNA2,E2F4,CCNE1,TFDP1,E2F1,CDK2) 1.84E-05
Protein Ubiquitination Pathway(USP28,PSMB9,DNAJC9,MED20,HSPA1A/HSPA1B,HSPH1,UBE2N,UBE2R2,HSPA6,CDC23,UBE2S,DNAJA1,HSPA5,TAP1,DNAJC11,USP31,USP3,PSMD12,USP46,USP34,BIRC) 5.29E-04
Adenine and Adenosine Salvage I(PNP) 5.89E-04
Phosphatidylglycerol Biosynthesis II (Non-plastidic)(GPAM,ABHD5,PTPMT1,MBOAT2) 6.36E-04
Cell Cycle: G1/S Checkpoint Regulation(E2F4,CCNE1,CCND2,TFDP1,E2F1,GNL3,CDK2) 7.40E-04
S. aureus- challenged vs. unchallenged control cells  
Canonical pathway (Genes involved in pathway) p -value
Phosphatidylglycerol Biosynthesis II (Non-plastidic)(GPAM,ABHD5,PTPMT1,MBOAT2) 4.27E-04
Protein Ubiquitination Pathway(DNAJC9,HSPA1A/HSPA1B,HSPH1,UBE2N,UBE2R2,HSPA6,DNAJC25,CDC23,UBE2S,DNAJA1,HSPA5,DNAJC11,PSMD12,USP46,USP34) 5.14E-04
Aldosterone Signaling in Epithelial Cells(ICMT,DNAJC9,HSPA1A/HSPA1B,HSPH1,HSPA6,DNAJC25,DNAJA1,HSPA5,PRKCZ,DNAJC11,PIK3R3,SCNN1G,PRKD1) 5.21E-04
Estrogen-mediated S-phase Entry(E2F4,CCNE1,TFDP1,E2F1) 1.69E-03
Vitamin-C Transport(SLC2A1,TXN,TXNRD1) 3.15E-03
  1. Top five categories of down-regulated canonical pathways in PMEC at 24 hpc with E. coli and S. aureus, respectively, compared with unchallenged control cells with their respective p-value and genes involved in each pathway obtained from IPA software.