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Table 4 Down-regulated canonical pathways in PMEC at 3 hpc

From: Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro

E. coli- challenged vs. unchallenged control cells  
Canonical pathway (Genes involved in pathway) p -value
BMP signaling pathway(SOSTDC1,JUN,BMP4,BMP2) 1.27E-04
Regulation of IL-2 Expression in Activated and AnergicT Lymphocytes(FOS,JUN,NFKBIA,VAV3) 1.55E-04
TGF-b Signaling(FOS,JUN,BMP4,BMP2) 1.79E-04
T Cell Receptor Signaling(FOS,JUN,NFKBIA,VAV3) 2.84E-04
PKCq Signaling in T Lymphocytes(FOS,JUN,NFKBIA,VAV3,MAP3K8) 4.80E-04
S. aureus- challenged vs. unchallenged control cells  
Canonical pathway (Genes involved in pathway) p -value
Differential Regulation of Cytokine Production inMacrophages and T Helper Cells by IL-17A and IL-17 F(CXCL1,CSF2) 1.75E-04
Role of Tissue Factor in Cancer(EGR1,CXCL1,JAK2,CSF2) 2.35E-04
Differential Regulation of Cytokine Production inIntestinal Epithelial Cells by IL-17A and IL-17 F (CXCL1,CSF2) 2.88E-04
IL-17A Signaling in Gastric Cells(FOS,CXCL1) 3.42E-04
MIF Regulation of Innate Immunity(FOS,PTGS2) 9.24E-04
  1. Top five categories of down-regulated canonical pathways in PMEC at 3 hpc with E. coli and S. aureus, respectively, compared with unchallenged control cells with their respective p-value and genes involved in each pathway obtained from IPA software.
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Veterinary Research

ISSN: 1297-9716