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Table 3 Up-regulated canonical pathways in PMEC at 24 hpc

From: Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro

E. coli- challenged vs. unchallenged control cells  
Canonical pathway (Genes involved in pathway) p -value
Interferon Signaling(IFIT3,IFIT1,PTPN2,MX1,TYK2,JAK2,STAT1,TAP1,IRF1) 1.31E-06
Hepatic Fibrosis/Hepatic Stellate Cell Activation(CXCL3,VCAM1,IL1A,CTGF,CCL2,ICAM1,FGF2,IGFBP3,TGFA, IGF1R,FGFR2,STAT1,FAS,COL3A1) 4.17E-06
Granulocyte Adhesion and Diapedesis(HRH1,CXCL3,VCAM1,IL1A,MMP7,ICAM1,SDC1,CLDN8, CCL2,CLDN1,CCL28,CXCL1,CXCL2,CXCL6,ITGB3) 7.71E-06
Agranulocyte Adhesion and Diapedesis(CXCL3,HRH1,VCAM1,IL1A,MMP7,ICAM1,CLDN8,CCL2,CLDN1,CCL28,CXCL1,CXCL2,CXCL6) 6.97E-05
HMGB1 Signaling(MAP2K6,PIK3R3,FOS,IL1A,VCAM1,ICAM1,RHOQ,CCL2,DIRAS3,FNBP1,KAT6B) 1.75E-04
S. aureus- challenged vs. unchallenged control cells  
Canonical pathway (Genes involved in pathway) p -value
Interferon Signaling(IFIT3,IFIT1,PTPN2,TYK2,JAK2,BCL2) 8.94E-04
Growth Hormone Signaling(PIK3R3,FOS,SOCS6,IGF1R,IGFBP3,RPS6KA5,SOCS4,JAK2,PRKCZ,PRKD1) 1.89E-03
Hepatic Fibrosis/Hepatic Stellate Cell Activation(VCAM1,CTGF,IGF1R,IGFBP3,FGFR2,SERPINE1,COL3A1,BCL2) 2.09E-03
Thrombopoietin Signaling(PIK3R3,FOS,IRS2,JAK2,PRKCZ,PRKD1) 5.34E-03
IGF-1 Signaling(PIK3R3,FOS,YWHAG,CTGF,SOCS6,IGF1R,IGFBP3,IRS2,SOCS4,JAK2,PRKCZ) 7.80E-03
  1. Top five categories of up-regulated canonical pathways in PMEC at 24 hpc with E. coli and S. aureus, respectively, compared with unchallenged control cells with their respective p-value and genes involved in each pathway obtained from IPA software.