Table 3 Up-regulated canonical pathways in PMEC at 24 hpc
E. coli- challenged vs. unchallenged control cells | |
|---|---|
Canonical pathway (Genes involved in pathway) | p -value |
Interferon Signaling(IFIT3,IFIT1,PTPN2,MX1,TYK2,JAK2,STAT1,TAP1,IRF1) | 1.31E-06 |
Hepatic Fibrosis/Hepatic Stellate Cell Activation(CXCL3,VCAM1,IL1A,CTGF,CCL2,ICAM1,FGF2,IGFBP3,TGFA, IGF1R,FGFR2,STAT1,FAS,COL3A1) | 4.17E-06 |
Granulocyte Adhesion and Diapedesis(HRH1,CXCL3,VCAM1,IL1A,MMP7,ICAM1,SDC1,CLDN8, CCL2,CLDN1,CCL28,CXCL1,CXCL2,CXCL6,ITGB3) | 7.71E-06 |
Agranulocyte Adhesion and Diapedesis(CXCL3,HRH1,VCAM1,IL1A,MMP7,ICAM1,CLDN8,CCL2,CLDN1,CCL28,CXCL1,CXCL2,CXCL6) | 6.97E-05 |
HMGB1 Signaling(MAP2K6,PIK3R3,FOS,IL1A,VCAM1,ICAM1,RHOQ,CCL2,DIRAS3,FNBP1,KAT6B) | 1.75E-04 |
S. aureus- challenged vs. unchallenged control cells | |
Canonical pathway (Genes involved in pathway) | p -value |
Interferon Signaling(IFIT3,IFIT1,PTPN2,TYK2,JAK2,BCL2) | 8.94E-04 |
Growth Hormone Signaling(PIK3R3,FOS,SOCS6,IGF1R,IGFBP3,RPS6KA5,SOCS4,JAK2,PRKCZ,PRKD1) | 1.89E-03 |
Hepatic Fibrosis/Hepatic Stellate Cell Activation(VCAM1,CTGF,IGF1R,IGFBP3,FGFR2,SERPINE1,COL3A1,BCL2) | 2.09E-03 |
Thrombopoietin Signaling(PIK3R3,FOS,IRS2,JAK2,PRKCZ,PRKD1) | 5.34E-03 |
IGF-1 Signaling(PIK3R3,FOS,YWHAG,CTGF,SOCS6,IGF1R,IGFBP3,IRS2,SOCS4,JAK2,PRKCZ) | 7.80E-03 |