Skip to main content

Table 2 Up-regulated canonical pathways in PMEC at 3 hpc

From: Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro

E. coli- challenged vs. unchallenged control cells  
Canonical pathway (Genes involved in pathway) p -value
Granulocyte Adhesion and Diapedesis(CXCL3,IL1A,VCAM1,ICAM1,CCL2,CLDN1,CXCL1,CXCL2,IL1RAP,CXCL6,ITGB3) 8.52E-11
Interferon Signaling(IFIT3,IFIT1,JAK2,IFNAR2,IFNAR1,IRF1) 4.11E-09
Agranulocyte Adhesion and Diapedesis(CXCL3,IL1A,VCAM1,ICAM1,CCL2,CLDN1,CXCL1,CXCL2,CXCL6) 4.92E-08
Hepatic Fibrosis/Hepatic Stellate Cell Activation(CXCL3,IL1A,VCAM1,ICAM1,CCL2,IFNAR2,IL1RAP,IFNAR1) 8.20E-08
Role of IL-17A in arthritis(CXCL3,NFKBIA,CCL2,CXCL1,CXCL6) 2.43E-06
S. aureus- challenged vs. unchallenged control cells  
Canonical pathway (Genes involved in pathway) p -value
Bupropion Degradation 3.44E-06
Acetone Degradation I (to Methylglyoxal) 3.86E-06
Estrogen Biosynthesis 1.11E-05
Nicotine Degradation III 2.87E-05
Melatonin Degradation I(CYP1A1,CYP3A4,CYP1B1 are involved in all five canonical pathways) 3.39E-05
  1. Top five categories of up-regulated canonical pathways in PMEC at 3 hpc with E. coli and S. aureus, respectively, compared with unchallenged control cells with their respective p-value and genes involved in each pathway obtained from IPA software.