Figure 1

Multiple sequence alignment of the deduced amino acid sequence at C-terminal region of the TGF-β superfamily members from F. hepatica and known TGF-β proteins. Conserved residues among TGF-β superfamily are shaded in black background, additional cysteine residues conserved among TGF-β subfamily member are shaded in grey. Accession numbers for sequences used in this analysis are: Bos taurus TGF-β1 (BtTGFb1), NP_001159540; B. taurus TGF-β2 (BtTGFb2), DAA21445.1; B. taurus TGF-β3 (BtTGFb3), DAA25016; B. taurus BMP4 (BtBMP4), NP_001039342; B. taurus BMP5 (BtBMP5), DAA16713.1; B. taurus BMP6 (BtBMP6), DAA16077.1; B. taurus BMP7 (BtBMP7), DAA23024.1; C. elegans DAF-7 (CeDaf7), NP497265.1; C. elegans Dpp BMP (CeDppBMP), AAB04986.2; C. elegans unc129 (Ceunc129), NP501566.1; C. sinensis inhibin β B chain (CsInhibin), GAA54687.1; C. sinensis BMP (CsBMP), GAA53092.1; C. sinensis DVR1 (CsDVR1), GAA43145.2; S. mansoni InAct (SmInAct), XP_002577586.1; S. mansoni BMP (SmBMP), ABL74278.1; S. japonicum BMP (SjBMP), ADM48811.1; H. microstoma TGF-β family (HmTGFb), CDJ10022.1; E. multilocularis activin (EmActivin), CCV01195.1; E. granulosus TGF-β (EgTGFb), CDJ22078.1.