Figure 3

Quantitative analysis of defined cell populations with immunohistochemistry. (A-B) Shown are the average (± SD) numbers of cells/ High Power Field, including T cells (CD3-positive) and B cells (CD20-positive) in the corpus of the stomach of mice. (C-D) Shown are the average (± SD) numbers of epithelial cells in five randomly chosen microscopic fields at the level of the gastric pits in the stomach from mice and Mongolian gerbils. An * represents a statistically significant difference (p < 0.05) between infected and control groups. An a represents a statistically significant difference (p < 0.05) between WT Helicobacter infected groups and isogenic ggt mutant infected groups. Ctr: animals from control group; HS: animals infected with WT H. suis strain HS5cLP; HSm: animals infected with H. suis strain HS5cLPΔggt; SS1: animals infected with WT H. pylori SS1; SS1m: animals infected with H. pylori SS1Δggt; PMSS1: animals infected with WT H. pylori PMSS1; PMSS1m: animals infected with H. pylori PMSS1Δggt; WT: wild-type; 3w: 3 weeks post infection; 9w: 9 weeks post infection; 6 m: 6 months post infection.