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Table 2 Genes in the DEHCnet involved in cell profileration, apoptosis and immune regulatory pathways

From: Genomic analysis of host – Peste des petits ruminants vaccine viral transcriptome uncovers transcription factors modulating immune regulatory pathways

Gene

Function

Reference

CSNK2A1

Plays key role in cellular growth and differentation. Suppressor of Apoptosis

[33]

EP400

Promotes cell cycle progression and inhibits induction of apoptosis or senescence.

[34]

NUB1

Role in cell cycle progression.

[35]

MKI67IP

Interacts with Ki-67 in proliferating cells and has a role in mitosis

[36]

TPD52L2

Regulator of cell proliferation. Marker for breast cancer and acute lymphoblastic leukemia.

[37]

RPS8

Role in apoptosis. Reacts with CDK11p46 and sensitizes cells for Fas ligand-induced apoptosis

[38]

PPP1CA

Regulates cell cycle progression and apoptosis.

[39]

BAG6

Represses function of Tim3 expressed on T cells during Hepatitis C virus infection. Regulates Apoptosis.

[40]

PPP5C

Regulates signaling cascades that suppress growth or induces apoptosis.

[41]

IFIT3

Induces antiviral response (anti-viral signaling) by inducing IFN-alpha.

[42]

CD3D

Involved in T cell development. Mutation in this gene leads to Immunodeficiency (SCID)

[43]

APP

Signaling molecule Involved in synaptic adhesion. Processed to form ß-amyloid peptides

[44]

VCP

Chaperon protein that regulates DNA damage and repair

[45]