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Figure 2 | Veterinary Research

Figure 2

From: Monoclonal antibody specific to HA2 glycopeptide protects mice from H3N2 influenza virus infection

Figure 2

Body weight changes and viral loads in the lungs of mice treated with mAb D7. Three groups of 6-week-old BALB/c mice were challenged with approximately 107 TCID50 of strains JS/10 (A, D), GD/12 (B, E) and SD/05 (C, F), respectively. In each virus group, mice were pretreated with 20 mg/kg of mAb D7, mAb IgG or PBS 1 day before viral challenge. Mice were monitored for body weight loss throughout the 14-day observation period. For body weight change (A, B, C), the results are expressed in terms of percent body weight. *P < 0.05, or **P < 0.01, indicates a significant difference in weight data for the mAb D7 treated groups compared with the virus-infected groups and irrelevant mAb IgG groups. # P < 0.05, indicates a significant difference in weight data for the PBS group compared with the mAb D7 treated group. For viral loads in the lungs (D, E, F), the results are expressed in terms of mean log10 number of copies/g of RNA standard deviation. *P < 0.05, or **P < 0.01, indicates a significantly different virus titer for the mAb D7 group compared with the other two groups. 2/3, and 1/3, indicate the proportion of the lungs in which virus could be detected.

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