Group no. | Animal | Sex | Age (in months) | Clinical signs and blood chemistry* | Gross lesions | Liver histopathology | Viral antigens in liver by IHC | |
---|---|---|---|---|---|---|---|---|
Grading | Distribution | |||||||
Group 1. Intravenous inoculation of wild boar | wb93 | ♀ | 3 | both with reduced feed intake, mild diarrhea, BA, ALT and γGT ↑ | in all animals mild hyperplasia of liver lymph nodes and lymphoid tissue in large intestine | both with panlobular hepatocellular swelling, vacuolation and single cell necrosis of hepatocytes | +++ | diffuse mainly in Kupffer cells and LSEC |
wb95 | ♀ | 3 | ++ |  | ||||
wb10 | ♂ | 6 | both with γGT ↑ | both with multifocal lymphoplasmacytic infiltrates and hepatocellular degeneration (mainly centrilobular) | +++ | mainly centrilobular in Kupffer cells associated with degenerated hepatocytes | ||
wb11 | ♀ | 6 | +++ | |||||
Group 2. Intravenous inoculation of miniature pigs | mp30** | ♀ | 3 | γGT ↑ (not in mp30) | nematodes in gut and milk spots in liver (mp39) | multifocal lymphoplasmacytic infiltrates and single cell necrosis of hepatocytes (mp37 and mp39) | 0 | diffuse mainly in Kupffer cells and LSEC |
mp37 | ♀ | 3 | + | |||||
mp39 | ♀ | 3 | ++ | |||||
mp40 | ♀ | 3 | 0 | |||||
Group 3. Contact infection of wild boar and miniature pigs | wb87 | ♂ | 3 | reduced feed intake, mild diarrhea, BA, ALT and γGT ↑ | mild hyperplasia of liver and intestinal lymph nodes, altered liver consistency and milk spots, moderate splenomegaly | intralobular lymphohistiocytic infiltrates and single cell necrosis of hepatocytes | ++ | mainly centrilobular in Kupffer cells and LSEC |
mp63 | ♀ | 3 | all with γGT ↑ | mild hyperplasia of lymphoid tissue in large intestine, nematodes in gut and renal cyst (mp68) | all with mild lymphohistiocytic infiltrates within liver lobules | 0 | - | |
mp68 | ♂ | 3 | 0 | |||||
mp79 | ♀ | 3 | 0 |