Table 3 Differential expression of key immune related genes between HPAIV infected chicken and duck cells (detected by microarray)
Gene symbol | Gene name | Entrez Gene ID | Chicken cells | Duck cells | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
H5N1-tyEng91 | H5N1-tyTR05 | H5N1-tyEng91 | H5N1-tyTR05 | |||||||
| Â | Â | Â | Fold change | Regulation | Fold change | Regulation | Fold change | Regulation | Fold change | Regulation |
JAK-STAT Pathway | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
STAT3 | signal transducer and activator of transcription 3 | 420027 | 2.33 | down | 2.72 | down | 1.39 | up | - | unchanged |
JAK1 | Janus kinase 1 (a protein tyrosine kinase) | 554219 | 2.79 | down | 3.21 | down | - | Removed* | - | Removed* |
IFNAR1 | Interferon (alpha, beta and omega) receptor 1 | 395665 | 8.02 | down | 16.65 | down | 13.91 | up | 1.37 | up |
PIAS2 | Protein inhibitor of activated STAT, 2 | 416383 | 5.05 | down | 3.86 | down | 1.62 | up | 3.7 | down |
Cytokines and Chemokines | ||||||||||
IL8/ CXCLi1(K60) | interleukin 8 | 395872 | 232.8 | up | 2.96 | up | - | unchanged | - | unchanged |
IL6 | interleukin 6 (interferon, beta 2) | 395337 | 131.08 | up | 10.66 | up | 2.92 | down | - | unchanged |
IL10 | interleukin 10 | 428264 | 1.39 | up | 1.6 | up | 1.39 | down | - | unchanged |
IL18 | interleukin 18 (interferon-gamma-inducing factor) | 395312 | 4.7 | down | 4.14 | down | 3.02 | up | 2.4 | up |