PRRSv RNA concentration (log10/μL or mg)
|
Serum cytokine levels (AUC)
|
PMA/Iono supernatant (AUC)
|
---|
IFNα
|
CCL2
|
IFNγ
|
IFNγ
|
---|
Serum (AUC)
|
P = 0.003
|
P < 0.001
|
ns
|
ns
|
β = 0.002134
|
β = 0.000104
|
Lung
|
ns
|
P = 0.010
|
ns
|
ns
|
β = 0.000010
|
Tonsil
|
P = 0.016
|
ns
|
P < 0.001
|
ns
|
β = 0.000185
|
β = −0.000115
|
Repro LN
|
ns
|
ns
|
ns
|
P = 0.002
|
β = −0.0000004
|
- The associations between cytokine levels over time (represented as area under curve (AUC)) and viral load in gilt serum and tissues are presented. P-values (regression coefficients, β) were obtained by univariate, multilevel mixed-effects regression models. Only analytes that were found to be significantly associated with viral load in either serum or any of the tested tissues are included. No association was found among cytokines in supernatants of PRRSv stimulated PBMC and viral load. Repro LN = reproductive lymph node. PMA/Iono supernatant AUC = AUC of IFNγ levels secreted from PMA/Iono stimulated PBMC from PRRSv infected gilts. ns = not significant (P > 0.01).