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Table 4 Results of the vaccination-challenge study (Study 4)

From: Immunogenicity and efficacy of fowlpox-vectored and inactivated avian influenza vaccines alone or in a prime-boost schedule in chickens with maternal antibodies

Group MDA Vaccine H5N8 HI titersa H5N9 HI titers Protectionb Oropharyngeal sheddingc
D0 D14 D14 D28 D28 (MDT) 2 Dpc 4 Dpc
1 - - - NDd 0/10 (2.0 ± 0.0) 0/10 (2.0 ± 0.0) 0/10 (2.0) 10/10 (7.8 ± 0.3) ND
2 - vFP89 - 10/10 (3.7 ± 0.8) 10/10 (5.5 ± 1.2) 8/10 (2.9 ± 0.6) 1/10 (3.4) 10/10 (6.3 ± 1.3) 5/5 (6.6 ± 0.7)
3 FP vFP89 inH5N9 2/9 (2.3 ± 0.7) 9/9 (8.1 ± 1.6) 9/9 (7.6 ± 1.8) 9/9 6/9 (4.6 ± 0.7) 4/9 (4.0 ± 0.5)
4 FP - inH5N9 ND 9/9 (5.1 ± 1.6) 9/9 (5.8 ± 0.7) 5/9 (7.3) 7/9 (4.9 ± 0.9) 4/9 (4.6 ± 1.0)
5 H5N9 - - ND 0/9 (2.0 ± 0.0) 0/9 (2.0 ± 0.0) 0/9 (2.0) 9/9 (7.3 ± 0.1) ND
6 H5N9 vFP89 - ND 5/9 (2.9 ± 0.9) 0/9 (2.0 ± 0.0) 0/9 (2.7) 9/9 (7.1 ± 0.5) 1/1 (7.7)
7 H5N9 vFP89 inH5N9 0/9 (2.0 ± 0.0) 9/9 (5.8 ± 1.0) 9/9 (4.3 ± 1.1) 7/9 (7.0) 6/9 (4.5 ± 0.6) 7/9 (4.6 ± 1.3)
8 H5N9 - inH5N9 0/9 (2.0 ± 0.0) 4/9 (3.2 ± 1.6) 6/9 (3.7 ± 1.7) 4/9 (5.0) 8/9 (5.0 ± 1.0) 7/8 (5.3 ± 1.1)
  1. Results of serology, protection and oropharyngeal viral shedding in chicks with or without FP or H5N9 MDA vaccinated or not with vFP89 and/or inH5N9 and challenged at D28 with an HPAI H5N1 Indonesian isolate (A/chicken/West Java-Subang/29/2007).
  2. aNumber of positive birds (HI titer ≥ 3 log2)/total; the mean HI titer ± standard deviation is given between brackets.
  3. bNumber of birds protected against mortality/total; the mean death time (MDT) is given between brackets.
  4. cNumber of positive birds (≥3.8 log10 EID50-equivalent)/total; the mean viral RNA load ± standard deviation is given in log10 EID50-equivalent between brackets; Dpc, day post-challenge.
  5. dND means not done.