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Table 3 H5N1 and H5N9 HI titers in breeders and their progeny

From: Immunogenicity and efficacy of fowlpox-vectored and inactivated avian influenza vaccines alone or in a prime-boost schedule in chickens with maternal antibodies

Study Type of breeders (age at egg harvest) HI titers*in breeders HI titers in progeny
Age at blood sampling H5N1 H5N9 H5N1 H5N9
1 H5N9 + FP (42 weeks) 36 weeks 4.0 ± 1.8 7.5 ± 2.2 2.0 ± 2.2 3.5 ± 3.0
44 weeks 2.9 ± 2.1 7.5 ± 2.5
2 H5N9 + FP (62 weeks) 60 weeks 3.5 ± 1.9 6.5 ± 2.7 1.0 ± 1.7 3.1 ± 2.7
68 weeks 3.0 ± 1.9 6.6 ± 2.1
3 H5N9 (24-25 weeks) 20 weeks 4.9 ± 2.0 7.1 ± 1.7 3.0 ± 1.9 4.3 ± 2.0
28 weeks 4.3 ± 2.5 5.9 ± 2.0
H5(N8) + H5N9 + FP (24-25 weeks) 20 weeks ND** 7.0 ± 1.6 1.8 ± 1.1 3.0 ± 1.9
28 weeks ND 5.3 ± 1.9
4 H5N9 (58 weeks) 52 weeks 3.9 ± 2.7 5.0 ± 2.1 ND 3.4 ± 0.9
60 weeks 4.6 ± 2.2 5.8 ± 2.3
  1. Breeders hens were vaccinated with inH5N9 and fowlpox (H5N9 + FP), inH5N9 only (H5N9) or with vFP89, inH5N9 and fowlpox (H5(N8) + H5N9 + FP). Their serums were taken at two time points flanking the time of harvest of their eggs. Serums of their progeny were sampled at 1 day-of-age. NIBRG14 and NIRG23 H5N1 antigens were used in studies 1 & 2 and studies 3 & 4, respectively.
  2. *mean HI titer ± standard deviation in log2.
  3. **ND means not done.