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Table 2 Amino acid sequence identity (up right) and similarity (down left) of the HA1 domain of the different H5 strains used for vaccines, challenge and/or HI test antigens

From: Immunogenicity and efficacy of fowlpox-vectored and inactivated avian influenza vaccines alone or in a prime-boost schedule in chickens with maternal antibodies

Identity →

tk/Ire/83 H5N8

ck/Ind/03 H5N1

ck/Ita/98 H5N9

Vtn/04 H5N1

tk/Tur/05 H5N1

ck/WJ/07 H5N1

Similarity ↓

tk/Ire/83 H5N8

 

88.0%

91.4%

88.7%

88.7%

83.4%

ck/Ind/03 H5N1

94.8%

 

89.3%

96.6%

96.0%

92.9%

ck/Ita/98 H5N9

96.3%

94.5%

 

89.6%

89.3%

85.3%

Vtn/04 H5N1

95.1%

97.5%

93.9%

 

94.8%

92.0%

tk/Tur/05 H5N1

94.2%

98.2%

93.9%

97.6%

 

90.5%

ck/WJ/07 H5N1

91.1%

94.8%

91.7%

94.2%

94.2%

 
  1. The HA gene of A/turkey/Ireland/1378/83 [H5N8] (tk/Ire/83 H5N8) and of A/chicken/Indonesia/7/2003 [H5N1 clade 2.1.1] (ck/Ind/03 H5N1) is inserted into the genome of fowlpox recombinant vFP89 and vFP2211, respectively. The A/chicken/Italy/22A/98 [H5N9] (ck/Ita/98 H5N9) is used in the inactivated inH5N9 vaccine. The NIBRG14 and NIBRG23 reverse genetics constructs contain the HA and NA genes from A/Vietnam/1194/2004 [H5N1 clade 1] (Vtn/04 H5N1) and from A/turkey/Turkey/1/2005 [H5N1 clade 2.2] (tk/Tur/05 H5N1), respectively. The A/chicken/West Java-Subang/29/2007 [H5N1 clade 2.1.3.2] (ck/WJ/07 H5N1) was used for the challenge in study 4.