Study | Chickens | 1stvaccination at day 0 | 2ndvaccination at day 21 (studies 1 and 2) or at day 14 (studies 3 and 4) | Challenge | ||
---|---|---|---|---|---|---|
Vaccine | Dose | Vaccine | Dose | |||
1 | SPF | vFP2211 | 103 TCID50 | - | - | No |
H5N9 + FP MDA | vFP2211 | 103 TCID50 | - | - | ||
vFP2211 | 105 TCID50 | - | - | |||
vFP2211 | 105 TCID50 | inH5N9 | 0.5 mL | |||
- | - | inH5N9 | 0.5 mL | |||
2 | H5N9 + FP MDA | inH5N9 | 0.2 mL | inH5N9 | 0.5 mL | No |
vFP89 | 103 TCID50 | inH5N9 | 0.5 mL | |||
SPF | vFP89 | 103 TCID50 | inH5N9 | 0.5 mL | ||
3 | SPF | vFP89 | 103 TCID50 | inH5N9 | 0.3 mL | No |
- | - | inH5N9 | 0.3 mL | |||
H5N9 MDA | vFP89 | 103 TCID50 | inH5N9 | 0.3 mL | ||
- | - | inH5N9 | 0.3 mL | |||
FP | vFP89 | 103 TCID50 | inH5N9 | 0.3 mL | ||
- | - | inH5N9 | 0.3 mL | |||
H5(N8)* + H5N9 + FP MDA | vFP89 | 103 TCID50 | inH5N9 | 0.3 mL | ||
4 | SPF | - | - | - | - | Yes (D28) |
vFP89 | 103 TCID50 | - | - | |||
FP MDA | vFP89 | 103 TCID50 | inH5N9 | 0.3 mL | ||
- | - | inH5N9 | 0.3 mL | |||
H5N9 MDA | - | - | - | - | ||
vFP89 | 103 TCID50 | - | - | |||
vFP89 | 103 TCID50 | inH5N9 | 0.3 mL | |||
- | - | inH5N9 | 0.3 mL |