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Table 3 Compilation of potentially virulence associated proteins identified in this work

From: Fine-tuned characterization of Staphylococcus aureus Newbould 305, a strain associated with mild and chronic mastitis in bovines

   Access.c    Methodf
Name of the proteina Locus nameb RF122 N305 Massd Loc.e Exo. Tot. Shav.
CELLULAR PROCESSES AND SIGNALING         
Cell cycle control, cell division, chromosome partitioning         
Probable transglycosylase IsaA isaA Q2YWD9 J0L078 28.2 S RF122   RF122, N305
Cell wall/membrane/envelope biogenesis         
Iron-regulated surface determinant protein A isdA Q2YX95 J0KNZ4   W    RF122, N305
Iron-regulated surface determinant protein B isdB Q2YX96 J1ET39 72.0 W RF122   RF122, N305
Iron-regulated surface determinant protein C isdC Q2YX94 J0KVY4      RF122, N305
Iron-regulated protein isdD Q2YX93 J0UGM1 41.2 U    RF122
Lipoteichoic acid synthase ltaS Q2YSL2 J1EW90 74.2 C/M RF122   
Penicillin-binding protein 2 pbp2 Q2YY56 J1EUU3 80.2 C/M    RF122
Post-translational modification, protein turnover, and chaperones         
Serine protease SplE splE Q2YTM5 J1EZ78 25.6 C/M N305   
Serine protease SplF splF Q2YTM6 J0KV93 25.6 S N305   
Serine protease SplD splD   J0L226 25.6 S N305   
Serine proteinase (SplB) Newbould 305_0049 Q2YTM3 J0UNB6 27.8 S N305   
Chaperone protein DnaK dnaK Q2YT47 J1EZS6 66.2 C   RF122 RF122, N305
Alkyl hydroperoxide reductase subunit F ahpF Q2YVH8 J0KUQ5 54.5 C/M   RF122 RF122, N305
Alkyl hydroperoxide reductase subunit C ahpC Q2YVK2 J1EYK8 20.9 C   RF122 RF122, N305
Trigger factor tig Q2YTB4 J0KVL9 48.4 C   N305 RF122, N305
Defense mechanisms         
Alkaline shock protein 23 asp23 Q2YYG3 J0KY19 18.6 U   N305 RF122, N305
INFORMATION STORAGE AND PROCESSING         
Replication, recombination and repair         
Thermonuclease nucI Q2YXU2 J0UHM2 21.8 S    RF122, N305
Translation, ribosomal structure and biogenesis         
Elongation factor Ts tsf Q2YXL1 J0KWZ6 32.3 C N305 RF122 N305
Elongation factor Tu tuf Q2YSB3 J1EVM7 43.0 C   N305 RF122, N305
METABOLISM         
Carbohydrate transport and metabolism         
Glyceraldehyde-3-phosphate dehydrogenase gap Q2YSF2 J0KSH5 36.2 C N305   RF122, N305
Glucose-6-phosphate isomerase pgi Q2YWS3 J0UKP5 49.7 C N305   
Enolase eno Q2YSE8 J1EWJ2 47.0 C N305   RF122, N305
Phosphoglycerate kinase pgk Q2YSF1 J1EWC9 42.5 C N305 N305 RF122, N305
Inorganic ion transport and metabolism         
Superoxide dismutase M sodM Q2YUU9 J0UM22 22.9 S N305   
POORLY CHARACTERIZED         
Gamma-hemolysin component A hlgA Q2YVZ2 J0KNX1 36.3 S    N305
Gamma-hemolysin component B hlgB Q2YVZ0 J0KVW4 36.6 S    RF122, N305
Gamma-hemolysin component C hlgC Q2YVZ1 J1ET20 35.5 S N305   
Staphylococcal enterotoxin C-bovine sec-bov Q2YVN9   31.2 S RF122   
Superantigen-like protein 7 set5 Q2YVR9 J1EYV6 26.0 S N305   
Superantigen-like protein set11 Q2YVM7 J1EYV1 25.7 S N305   
Superantigen-like protein set19   J0UMW3 39.8 S    N305
Superantigen-like protein Newbould 305_1808 Q2YXF4 J0KPN6 27.7 S    N305
Leukocidin F subunit lukA Q2YU84 J1ET76 38.6 S    RF122, N305
Leukocidin S subunit lukB Q2YU83 J0KP92 40.2 S    N305
Panton-Valentine leukocidin LukF’-PV chain lukF’-PV Q2YWM7   36.4 S    RF122
Leukocidin chain lukM lukM Q2YWM8   35.0 S    RF122
Leukotoxin E subunit lukE Q2YTQ3 J0L217 34.6 S    RF122, N305
Extracellular matrix and plasma binding protein Newbould 305_1324   J0UKH8 38.3 W    N305
Uncharacterized protein (vwbSbo5-like) Newbould 305_0962   J0KUT2 57.4 S    N305
Immunoglobulin G binding protein A (Protein A) spa   J1EXZ6 56.8 W    N305
Elastin-binding protein EbpS ebpS Q2YY76 J0KQY7 52.9 C/M    RF122, N305
Molecular chaperone Hsp31 and glyoxalase 3 hchA   J1EVT7 32.0 C   N305  
  1. aProteins are classified in COG. Names are given according to annotation of genome sequences
  2. bCorrespond to the commonly found name of the gene.
  3. cAccessions numbers are given according to references on UniProtKB [35].
  4. d Theoretical mass (in kDa) as predicted from the protein sequence [36].
  5. ePredicted localization based on PSORTb software. S = Extracellular C = Cytoplasmic C/M = Cytoplasmic/Membrane W = Cell wall U = Unknown.
  6. fMethod that enabled the observation of the protein with the name of the strain in which the protein was identified: Exo. = Proteins identified in supernatant Tot. =Proteins identified in total lysate Shav. =Proteins present in trypsin shaving solution.