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Table 3 Compilation of potentially virulence associated proteins identified in this work

From: Fine-tuned characterization of Staphylococcus aureus Newbould 305, a strain associated with mild and chronic mastitis in bovines

  

Access.c

  

Methodf

Name of the proteina

Locus nameb

RF122

N305

Massd

Loc.e

Exo.

Tot.

Shav.

CELLULAR PROCESSES AND SIGNALING

        

Cell cycle control, cell division, chromosome partitioning

        

Probable transglycosylase IsaA

isaA

Q2YWD9

J0L078

28.2

S

RF122

 

RF122, N305

Cell wall/membrane/envelope biogenesis

        

Iron-regulated surface determinant protein A

isdA

Q2YX95

J0KNZ4

 

W

  

RF122, N305

Iron-regulated surface determinant protein B

isdB

Q2YX96

J1ET39

72.0

W

RF122

 

RF122, N305

Iron-regulated surface determinant protein C

isdC

Q2YX94

J0KVY4

    

RF122, N305

Iron-regulated protein

isdD

Q2YX93

J0UGM1

41.2

U

  

RF122

Lipoteichoic acid synthase

ltaS

Q2YSL2

J1EW90

74.2

C/M

RF122

  

Penicillin-binding protein 2

pbp2

Q2YY56

J1EUU3

80.2

C/M

  

RF122

Post-translational modification, protein turnover, and chaperones

        

Serine protease SplE

splE

Q2YTM5

J1EZ78

25.6

C/M

N305

  

Serine protease SplF

splF

Q2YTM6

J0KV93

25.6

S

N305

  

Serine protease SplD

splD

 

J0L226

25.6

S

N305

  

Serine proteinase (SplB)

Newbould 305_0049

Q2YTM3

J0UNB6

27.8

S

N305

  

Chaperone protein DnaK

dnaK

Q2YT47

J1EZS6

66.2

C

 

RF122

RF122, N305

Alkyl hydroperoxide reductase subunit F

ahpF

Q2YVH8

J0KUQ5

54.5

C/M

 

RF122

RF122, N305

Alkyl hydroperoxide reductase subunit C

ahpC

Q2YVK2

J1EYK8

20.9

C

 

RF122

RF122, N305

Trigger factor

tig

Q2YTB4

J0KVL9

48.4

C

 

N305

RF122, N305

Defense mechanisms

        

Alkaline shock protein 23

asp23

Q2YYG3

J0KY19

18.6

U

 

N305

RF122, N305

INFORMATION STORAGE AND PROCESSING

        

Replication, recombination and repair

        

Thermonuclease

nucI

Q2YXU2

J0UHM2

21.8

S

  

RF122, N305

Translation, ribosomal structure and biogenesis

        

Elongation factor Ts

tsf

Q2YXL1

J0KWZ6

32.3

C

N305

RF122

N305

Elongation factor Tu

tuf

Q2YSB3

J1EVM7

43.0

C

 

N305

RF122, N305

METABOLISM

        

Carbohydrate transport and metabolism

        

Glyceraldehyde-3-phosphate dehydrogenase

gap

Q2YSF2

J0KSH5

36.2

C

N305

 

RF122, N305

Glucose-6-phosphate isomerase

pgi

Q2YWS3

J0UKP5

49.7

C

N305

  

Enolase

eno

Q2YSE8

J1EWJ2

47.0

C

N305

 

RF122, N305

Phosphoglycerate kinase

pgk

Q2YSF1

J1EWC9

42.5

C

N305

N305

RF122, N305

Inorganic ion transport and metabolism

        

Superoxide dismutase M

sodM

Q2YUU9

J0UM22

22.9

S

N305

  

POORLY CHARACTERIZED

        

Gamma-hemolysin component A

hlgA

Q2YVZ2

J0KNX1

36.3

S

  

N305

Gamma-hemolysin component B

hlgB

Q2YVZ0

J0KVW4

36.6

S

  

RF122, N305

Gamma-hemolysin component C

hlgC

Q2YVZ1

J1ET20

35.5

S

N305

  

Staphylococcal enterotoxin C-bovine

sec-bov

Q2YVN9

 

31.2

S

RF122

  

Superantigen-like protein 7

set5

Q2YVR9

J1EYV6

26.0

S

N305

  

Superantigen-like protein

set11

Q2YVM7

J1EYV1

25.7

S

N305

  

Superantigen-like protein

set19

 

J0UMW3

39.8

S

  

N305

Superantigen-like protein

Newbould 305_1808

Q2YXF4

J0KPN6

27.7

S

  

N305

Leukocidin F subunit

lukA

Q2YU84

J1ET76

38.6

S

  

RF122, N305

Leukocidin S subunit

lukB

Q2YU83

J0KP92

40.2

S

  

N305

Panton-Valentine leukocidin LukF’-PV chain

lukF’-PV

Q2YWM7

 

36.4

S

  

RF122

Leukocidin chain lukM

lukM

Q2YWM8

 

35.0

S

  

RF122

Leukotoxin E subunit

lukE

Q2YTQ3

J0L217

34.6

S

  

RF122, N305

Extracellular matrix and plasma binding protein

Newbould 305_1324

 

J0UKH8

38.3

W

  

N305

Uncharacterized protein (vwbSbo5-like)

Newbould 305_0962

 

J0KUT2

57.4

S

  

N305

Immunoglobulin G binding protein A (Protein A)

spa

 

J1EXZ6

56.8

W

  

N305

Elastin-binding protein EbpS

ebpS

Q2YY76

J0KQY7

52.9

C/M

  

RF122, N305

Molecular chaperone Hsp31 and glyoxalase 3

hchA

 

J1EVT7

32.0

C

 

N305

 
  1. aProteins are classified in COG. Names are given according to annotation of genome sequences
  2. bCorrespond to the commonly found name of the gene.
  3. cAccessions numbers are given according to references on UniProtKB [35].
  4. d Theoretical mass (in kDa) as predicted from the protein sequence [36].
  5. ePredicted localization based on PSORTb software. S = Extracellular C = Cytoplasmic C/M = Cytoplasmic/Membrane W = Cell wall U = Unknown.
  6. fMethod that enabled the observation of the protein with the name of the strain in which the protein was identified: Exo. = Proteins identified in supernatant Tot. =Proteins identified in total lysate Shav. =Proteins present in trypsin shaving solution.
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Veterinary Research

ISSN: 1297-9716