Table 3 Summary of the efficacy data in different target species after vaccination with SAG2 vaccine administered either by direct instillation in the mouth or by bait consumption

Red fox

± 12 months

5 p.o.

10⁷ p.f.u.

29 days

5/5

5/5

0/5

[31]

± 12 months

5 p.o.

10⁸ p.f.u.

5/5

5/5

0/5

± 12 months

5 controls

-

0/5

0/5

5/5

Red fox

± 9 months

6 p.o.

10^7.5 p.f.u.

85 days

6/6

6/6

0/6

[26]

± 9 months

2 controls

-

0/2

0/2

2/2

± 9 months

5 p.o.

10^7.5 p.f.u.

220 days

5/5

5/5

0/5

± 9 months

1 control

-

0/1

0/1

1/1

± 9 months

6 p.o.

10^7.5 p.f.u.

303 days

6/6

6/6

0/6

± 9 months

2 controls

-

0/2

0/2

Red fox

13-14 months

5 p.o. (bait)

10^7.0 CCID₅₀

30 days

5/5

4/5

1/5

[26]

5 p.o. (bait)

10^8.0 CCID₅₀

5/5

4/5

1/5

5 p.o. (bait)

10^9.0 CCID₅₀

5/5

5/5

0/5

2 controls

-

0/2

0/2

2/2

Red fox

6.4 months to 4.5 years

25 p.o. (bait)

10^8.0 CCID₅₀

180 days

21/25

22/25

3/25

[26]

10 controls

-

0/10

0/10

10/10

Raccoon dog

6 months

29 p.o. (23 bait, 6 instill)

10^8.15 CCID₅₀

201 days

29/29

28/28

0/28

[35]

6 months

12 controls

-

0/12

0/11

11/11

Side-striped jackal

≥ 9 months

3 p.o. (instill)

10^6.5 CCID₅₀

6 months

2/3

3/3

0/3

[30]

≥ 9 months

3 p.o. (instill)

10^7.5 CCID₅₀

2/3

2/3

1/3

≥ 9 months

3 controls

-

0/3

0/3

3/3

Black-backed jackal

≥ 9 months

3 p.o. (instill)

10^6.5 CCID₅₀

6 months

3/3

3/3

0/3

[30]

≥ 9 months

3 p.o. (instill)

10^7.5 CCID₅₀

3/3

3/3

0/3

≥ 9 months

2 controls

-

0/2

0/2

2/2

Side-striped jackal

≥ 9 months

5 p.o. (bait)

10^8.25 CCID₅₀

30 days

5/5

5/5

[30]

≥ 9 months

5 p.o. (bait)

10^7.25 CCID₅₀

3/5

3/5

≥ 9 months

5 controls

0/5

0/5

Golden jackals

≥ 9 months

14 p.o. (bait)

10^8.0 CCID₅₀

160 days

11/14

12/14 (85.7%)

[50]

≥ 9 months

10 controls

-

0/10

0/10 (0%)

Arctic fox

10 p.o. (bait)

10^7.75 SMICLD₅₀

7 weeks

10/10

10/10

0/10

[52]

4 controls

-

0/4

1/4

3/4

Raccoon

adult

5 p.o. (instill)

10^9.0 TCID₅₀

30 days

3/5

5/5

0/5

[55]

adult

5 controls

-

0/5

0/5

5/5

Striped skunk

adult

5 p.o. (instill)

10^9.0 TCID₅₀

30 days

2/5

5/5

0/5

[55]

adult

5 controls

-

0/5

0/4*

4/5

Coyotes

unknown

4 p.o. (liquid bait form)

10^7.3 TCID₅₀

30 days

2/4

3/4

1/4

(Rupprecht et al.: Efficacy of SAG2 for oral vaccination of coyotes against rabies, unpublished)

unknown

4 p.o. (liquid bait form)

10^8.3 TCID₅₀

3/4

4/4

0/4

unknown

4 p.o. (liquid bait form)

10^9.6 TCID₅₀

4/4

4/4

0/4

unknown

5 p.o. (lyophilized bait form)

10^6.9 TCID₅₀

3/5

2/5

3/5

unknown

5 p.o. (lyophilized bait form)

10^7.2 TCID₅₀

3/5

4/5

1/5

unknown

5 p.o. (lyophilized bait form)

10^8.3 TCID₅₀

5/5

5/5

0/5

unknown

5 controls

0/5

0/5

5/5