Table 1 Summary of the safety data after oral administration of high doses of SAG2 vaccine to foxes and raccoon dogs
From: Twenty year experience of the oral rabies vaccine SAG2 in wildlife: a global review
Species | No of animals, route (mean age) | SAG dose per animal | Time of observation | Specific morbidity/mortality | Virus isolation from saliva swabs | Rabies virus positive brains | Rabies virus positive salivary glands | Seroconversion | Source |
|---|---|---|---|---|---|---|---|---|---|
Fox | 10 p.o. (6Â months to 2.5Â years) | 109.8 CCID50 | 183Â days | 0/10 | 0/10 (D0, D1, D3, D7) | 0/10 | 0/10 | 10/10 | [26] |
| Â | 10 p.o. (9Â months) | 109 p.f.u. | 175Â days | 0/10 | 0/10 (D1, D3, D6) | 0/10 | 0/10 | 10/10 | Â |
Raccoon dog | 5 p.o. instillation (6Â months) | 1010.0 CCID50 | 60Â days | 0/5 | Â | 0/5 | 0/5 | 5/5 | [35] |
| Â | 5 p.o. bait (6Â months) | 109.9 CCID50 | 60Â days | 0/5 | Â | 0/5 | 0/5 | 5/5 | Â |