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Table 4 Efficacy of B. ovis LPS mutants in BALB/c mice against a virulent B. ovis infection

From: Mutants in the lipopolysaccharide of Brucella ovis are attenuated and protect against B. ovis infection in mice

Vaccine (dose/route) Log10CFU in spleen (mean ± SD) No. of non-infected/ total mice studied
BoΔwadB (108/IP) 1.08 ± 1.22a,c 7/10a,c
BoΔwadC (108/IP) 2.18 ± 1.59a 5/10b
B. melitensis Rev 1 (105/SC) 2.75 ± 1.26b 2/10
PBS (unvaccinated control) 6.24 ± 0.48c 0/10
  1. ap < 0.005 and , bp < 0.05 vs. unvaccinated control; cp < 0.05 vs. Rev 1 control.