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Table 3 Colonization of B. ovis PA and the LPS mutant strains in mouse spleens

From: Mutants in the lipopolysaccharide of Brucella ovis are attenuated and protect against B. ovis infection in mice

B. ovisstrain

log10CFU in spleen

3 weeks post infection

10 weeks post infection

mean ± SD

mean ± SD

Cleared/Totals

B. ovis PA

6.56 ± 0.52

4.67 ± 0.86

0/5

BoΔwadA

6.78 ± 0.40

4.41 ± 2.01

0/5

BoΔwadB

2.31 ± 1.91a

0.80 ± 0.42a

5/5a

BoΔwadC

3.82 ± 0.72a

1.11 ± 0.77a

4/5a

BoΔwadB-revb

5.89 ± 0.77

4.90 ± 0.45

0/5

BoΔwadC-revb

6.49 ± 0.23

4.71 ± 1.68

0/5

  1. Statistical comparison (n = 5) of mean log CFU/spleen or percentage of mice found free from infection in spleens by totals, respectively: aP < 0.005 vs. B. ovis PA; bSibling revertant mutants.