Bovinized mice are responsive to WME. (A) Representative image of pbIL-8-Luc bovinized mice treated with saline (n = 3), WME 1X or WME 10X. Mice were monitored before the treatment to get the baseline and at 4, 24 and 48 h post treatment by in vivo image analysis drawing a region of interest (ROI) over the chest and using an IVIS imaging system (Caliper Life Sciences, Alameda, CA). Light emitted was acquired from specific regions by Living Image® software (Caliper Life Sciences, Alameda, CA) and expressed as photon/second/cm2 (photon/s/cm2) (B) and normalized as fold of induction versus baseline (FOI Vs. Baseline) (C). Statistical differences were tested by One Way ANOVA followed by Dunnet’s post hoc test for group comparisons. Results are reported as mean ± SD and significance attributed when P < 0.05 (*) or P < 0.01 (**).