Neonatal influenza infection causes pathological changes in the mouse brain

Table 2 Immunohistochemical distribution of viral antigen in infected mouse brain

Dpi*	No.**	Localization of viral antigens***
Dpi*	No.**	Cerebral cortex	Hippocampus	Diencephalon	Midbrain	Pons	Medulla oblongata	Cerebellum
1	1	-	-	-	+	+	+	-
	2	-	-	+	+	-	+	-
	3	-	-	-	+	+	+	-
2	1	+/-	-	-	-	-	-	+/-
	2	+/-	-	-	-	-	+	+/-
	3	-	-	-	-	+	+	+/-
3	1	-	-	-	-	-	+	+
	2	-	-	-	-	-	+/-	+/-
	3	-	-	-	-	-	+/-	+/-
4	1	-	-	-	-	-	-	+/-
	2	+	-	+	-	-	+	+/-
	3	+	-	+	+	+	+	+
5	1	+	+	+	+	-	-	-
	2	+	-	+	+	+	+	+
	3	+	-	+	+	+	+	+
7	1	-	-	-	-	-	-	-
	2	-	-	-	-	-	-	-
	3	-	-	-	-	-	-	-

The temporal and spatial localization of virus was evaluated by the presence and intensity. No viral antigen was detected at 10, 15, and 21 dpi (data not shown). (*: Days post infection; **: n = 3/days post-infection; ***: -, negative signal; +/-. weak signal; +, positive signal).

ISSN: 1297-9716