Down-regulation of mechanisms involved in cell transport and maintenance of mucosal integrity in pigs infected with Lawsonia intracellularis

Table 3 Altered cellular networks at 14 dpc identified using ingenuity pathway analysis

Network functions	Score	Focus molecules
Cancer, Gastrointestinal Disease, Cellular Function & Maintenance	53	25
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	44	22
Cellular Function & Maintenance, Developmental Disorder, Endocrine System Disorders	28	16
Cell Morphology, Organ Morphology, Molecular Transport	27	15
Endocrine System Disorders, Reproductive System Disease, Developmental Disorder	24	14
Energy Production, Lipid Metabolism, Small Molecule Biochemistry	20	12
Gastrointestinal Disease, Inflammatory Disease, Inflammatory Response	20	12
Cell-To-Cell Signalling and Interaction, Cell Signalling, Behaviour	10	7

Eight cellular networks most frequently associated with altered gene expression in L. intracellularis infected pig ileum. As described by [31], the network function score ranks the network and takes into account the number of Network Eligible molecules in the network and its size, as well as the total number of Network Eligible molecules analysed and the total number of molecules in the Ingenuity Knowledge Base that could potentially be included in networks.

ISSN: 1297-9716