Evaluation of a 3A-truncated foot-and-mouth disease virus in pigs for its potential as a marker vaccine

Table 4 The result of the PD ₅₀ test of the r-HN/3A _93–143 vaccine

Vaccine dose^a	Pig	Protection^b	LPBE-antibody^c(dpi)	3ABC antibody^d(dpi)
1	1501	yes	1:512	–
	1503	yes	1:256	–
	1504	yes	1:128	–
	1528	yes	1:64	–
	1536	yes	1:256	–
1/3	1502	yes	1:128	–
	1506	yes	1:32	–
	1529	yes	1:256	–
	1534	yes	1:64	–
	1533	yes	1:256	–
1/9	1505	yes	1:64	–
	1507	yes	1:128	–
	1527	no	< 1:6	+
	1532	no	< 1:6	+
	1535	yes	1:512	–
control	026	no	< 1:6	+
control	030	no	< 1:6	+

^a2 μg per dose of binary ethyleimine-inactivated antigen vaccine.
^bPigs were challenged by intramuscular inoculation of 1000 ID₅₀ of r-HN.
^cLPBE-antibody, liquid-phase blocking ELISA antibody. Dpi here indicates four-weeks after vaccination that LPBE-antibodies were detected.
^d3ABC antibody, the antibody to the nonstructural protein 3ABC of FMDV. dpi here indicates three-weeks after challenge that 3ABC antibodies were detected. +, positive, −, negative.

ISSN: 1297-9716