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Table 1 Clinical symptoms and virus recovery from pigs inoculated with CSFVs

From: Npro of classical swine fever virus contributes to pathogenicity in pigs by preventing type I interferon induction at local replication sites

   Virus recovery from:
Inoculated virus Clinical symptoms Blood (log10TCID50/mL)on days pi Tissue (log10TCID50/g)§
3 5 7 9 11 14 Brain Tonsils Spleen Kidneys Adrenal glands Mesenteric lymph node Colon
vGPE- - - - - - - - - - - - - - -
- + - - - - - - + - - - - -
- - - - - - - - + - - - - -
- - + - - - - - + - - - - -
- - + - - - - - + - - - - -
vGPE-/N136D - + - - - - - - + - - - - -
- ≤ 1.6 - - - - - - ≤ 2.3 - - - - -
- + - - - - - - ≤ 2.1 - - - - -
- - - - - - - - - - - - - -
- - - - - - - - + - - - - -
vGPE-/T830A; V2475A; A2563V Cyanosis ≤ 1.0 ≤ 2.1 ≤ 1.0 ≤ 1.0 - - - 4.0 - - - - -
- ≤ 1.0 2.6 3.6 ≤ 2.6 + - - 3.3 - - - + -
Weight loss, cyanosis ≤1.1 2.8 ≤ 2.3 ≤ 1.3 - - - 3.7 - - - - -
Cyanosis ≤ 1.0 2.6 2.0 ≤ 1.0 - - - 3.0 - - - - -
Diarrhea, cyanosis ≤ 2.1 2.3 2.6 3.1 + - - 4.1 - - - ≤ 2.3 -
vGPE-/N136D; T830A; V2475A; A2563V Weight loss, coarse fur, cyanosis, astasia 2.6 4.8 5.3 5.6 5.1 4.6 4.3 7.0 6.3 5.6 5.8 6.0 5.8
Weight loss, coarse fur 3.3 4.0 4.3 4.6 4.3 ≤ 1.3 - ≤ 3.8 ≤ 2.3 - + 3.0 ≤ 2.3
Astasia, arthritis 3.3 4.0 3.6 + - - - 3.0 ≤ 2.1 - - ≤ 2.0 -
Weight loss, arthritis 2.8 3.6 2.9 + - - - 4.1 - 3.8 - ≤ 2.0 -
Weight loss, coarse fur 2.3 4.3 4.0 3.8 + - - 4.0 ≤ 2.0 ≤ 3.1 ≤ 2.3 ≤ 2.5 -
vEy-37 Fever, cyanosis, weight loss 5.5 5.0 5.8 6.0 5.8 4.6 6.0 6.8 7.6 7.8 6.0 8.0 7.0
Low-sproted, anorexia, diarrhea, weight loss, cyanosis, death 4.0 6.0 6.6 NT NT NT 6.1 7.0 6.6 5.3 6.0 7.0 5.5
Fever, low-sproted, anorexia, diarrhea, cyanosis, death 5.3 6.1 6.1 NT NT NT 5.0 6.6 6.3 5.6 5.3 6.8 5.8
Fever, anorexia, diarrhea, weight loss, cyanosis 5.3 6.6 6.7 6.0 6.0 5.1 6.0 7.3 6.8 7.6 6.6 7.5 4.6
  Fever, anorexia, diarrhea, weight loss, cyanosis 4.8 6.0 6.0 6.0 6.8 6.6 6.3 7.6 7.8 7.5 6.8 8.0 7.8
  1. -: not observed.
  2. -: not isolated, NT: not tested, +: isolated in a 6-well plate and was lower detection limit of TCID50 (100.8 TCID50/mL) in a 96-well plate.
  3. §-: not isolated, +: isolated in a 6-well plate and was lower detection limit of TCID50 (101.8 TCID50/mL) in a 96-well plate.