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Table 1 Clinical symptoms and virus recovery from pigs inoculated with CSFVs

From: Npro of classical swine fever virus contributes to pathogenicity in pigs by preventing type I interferon induction at local replication sites

  

Virus recovery from:

Inoculated virus

Clinical symptoms†

Blood (log10TCID50/mL)‡on days pi

Tissue (log10TCID50/g)§

3

5

7

9

11

14

Brain

Tonsils

Spleen

Kidneys

Adrenal glands

Mesenteric lymph node

Colon

vGPE-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

+

-

-

-

-

-

-

+

-

-

-

-

-

-

-

-

-

-

-

-

-

+

-

-

-

-

-

-

-

+

-

-

-

-

-

+

-

-

-

-

-

-

-

+

-

-

-

-

-

+

-

-

-

-

-

vGPE-/N136D

-

+

-

-

-

-

-

-

+

-

-

-

-

-

-

≤ 1.6

-

-

-

-

-

-

≤ 2.3

-

-

-

-

-

-

+

-

-

-

-

-

-

≤ 2.1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

+

-

-

-

-

-

vGPE-/T830A; V2475A; A2563V

Cyanosis

≤ 1.0

≤ 2.1

≤ 1.0

≤ 1.0

-

-

-

4.0

-

-

-

-

-

-

≤ 1.0

2.6

3.6

≤ 2.6

+

-

-

3.3

-

-

-

+

-

Weight loss, cyanosis

≤1.1

2.8

≤ 2.3

≤ 1.3

-

-

-

3.7

-

-

-

-

-

Cyanosis

≤ 1.0

2.6

2.0

≤ 1.0

-

-

-

3.0

-

-

-

-

-

Diarrhea, cyanosis

≤ 2.1

2.3

2.6

3.1

+

-

-

4.1

-

-

-

≤ 2.3

-

vGPE-/N136D; T830A; V2475A; A2563V

Weight loss, coarse fur, cyanosis, astasia

2.6

4.8

5.3

5.6

5.1

4.6

4.3

7.0

6.3

5.6

5.8

6.0

5.8

Weight loss, coarse fur

3.3

4.0

4.3

4.6

4.3

≤ 1.3

-

≤ 3.8

≤ 2.3

-

+

3.0

≤ 2.3

Astasia, arthritis

3.3

4.0

3.6

+

-

-

-

3.0

≤ 2.1

-

-

≤ 2.0

-

Weight loss, arthritis

2.8

3.6

2.9

+

-

-

-

4.1

-

3.8

-

≤ 2.0

-

Weight loss, coarse fur

2.3

4.3

4.0

3.8

+

-

-

4.0

≤ 2.0

≤ 3.1

≤ 2.3

≤ 2.5

-

vEy-37

Fever, cyanosis, weight loss

5.5

5.0

5.8

6.0

5.8

4.6

6.0

6.8

7.6

7.8

6.0

8.0

7.0

Low-sproted, anorexia, diarrhea, weight loss, cyanosis, death

4.0

6.0

6.6

NT

NT

NT

6.1

7.0

6.6

5.3

6.0

7.0

5.5

Fever, low-sproted, anorexia, diarrhea, cyanosis, death

5.3

6.1

6.1

NT

NT

NT

5.0

6.6

6.3

5.6

5.3

6.8

5.8

Fever, anorexia, diarrhea, weight loss, cyanosis

5.3

6.6

6.7

6.0

6.0

5.1

6.0

7.3

6.8

7.6

6.6

7.5

4.6

 

Fever, anorexia, diarrhea, weight loss, cyanosis

4.8

6.0

6.0

6.0

6.8

6.6

6.3

7.6

7.8

7.5

6.8

8.0

7.8

  1. †-: not observed.
  2. ‡-: not isolated, NT: not tested, +: isolated in a 6-well plate and was lower detection limit of TCID50 (100.8 TCID50/mL) in a 96-well plate.
  3. §-: not isolated, +: isolated in a 6-well plate and was lower detection limit of TCID50 (101.8 TCID50/mL) in a 96-well plate.
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Veterinary Research

ISSN: 1297-9716