Table 1 Viral load of organs in tissue culture infectious dose 50 (TCID50) and genome copies
From: Limited efficacy of West Nile virus vaccines in large falcons (Falco spp.)
Group | Bird | dpi | Brain | Spleen | Kidney | Lung | Liver | Heart |
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | TCID50/mg/copies/mg | TCID50/mg/copies/mg | TCID50/mg/copies/mg | TCID50/mg/copies/mg | TCID50/mg/copies/mg | TCID50/mg/copies/mg |
Group 1 | F14 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Inactivated | F15 | 19 | 0/4.6 | 0/0.4 | 0/0.9 | 0/0 | 0/0.1 | 0/0 |
Boost: 4 wpv | F16 | 20 | 0/24.8 | 0/3.8 | 0/143 | 0/0 | 0/0 | 0/1.8 |
Challenge: 8 wpv | F17 | 9 | 18.7/2530 | 0/3441 | 0.2/4479 | 0/6583 | 0/290 | 1164/38565819 |
F18 | 21 | 0/4.7 | 0/0.9 | 0/223 | 0/0 | 0/0.1 | 0/2.6 | |
Group 2 | F37 | 19 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Inactivated | F38 | 20 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0.2 | 0/0 |
Boost: 3 + 6 wpv | F40 | 19 | 0/0.6 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Challenge: 8 wpv | F41 | 20 | 0/0 | 0/1.4 | 0/0 | 0/0 | 0/0 | 0/0 |
Group 3 | F19 | 20 | 0/0 | 0/0 | 0/0.6 | 0/0 | 0/0 | 0/0 |
Recombinant | F20 | 19 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Boost: 4 wpv | F21 | 21 | 50.8/4337 | 0/0 | 0/141 | 0/0 | 0/0 | 0/0 |
Challenge: 8 wpv | F22 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
F23 | 20 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | |
Group 4 | F44 | 20 | 0/6 | 0/0.1 | 0/0 | 0/0 | 0/0 | 0/0 |
Recombinant | F45 | 19 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Boost: 3 + 6 wpv | F47 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Challenge: 8 wpv | F48 | 19 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Group 5 | F13 | 19 | 0.6/112 | 0/17.9 | 0/3.9 | 0/0.1 | 0/0.3 | 0/4.6 |
Control | F24 | 20 | 0/32.1 | 0/0 | 0/822 | 0/0 | 0/0 | 0/4.7 |
No vaccination | F27 | 14 | 8.7/132202 | 0/42 | 0/403 | 0/36.9 | 0/16.7 | 37.9/7794 |
F36 | 20 | 0/23.6 | 0/0 | 0/2 | 0/0 | 0/0 | 0/0 | |
F42 | 5 | 46.9/515 | 175/318323 | 76.2/14400 | 601/5456 | 94.4/32119 | 19/6563 | |
F43 | 20 | 0.4/38.2 | 0/11.4 | 0/1.5 | 0/0 | 0/0.1 | 0/0.1 | |
F51 | 8 | 738/2668 | 10.7/8631 | 2896/82091 | 7558/63844 | 3023/402895 | 4380/295311 | |
F55 | 3 | 0/12.3 | 3.3/2376 | 3.9/796 | 13.2/465 | 0.9/249 | 5.4/380 | |
Group 6 | F63 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Env. Control |