Recombinant adenovirus expressing the haemagglutinin of peste des petits ruminants virus (PPRV) protects goats against challenge with pathogenic virus; a DIVA vaccine for PPR

Table 3 PPRV in the nasopharynx 7 days post challenge (pc)

Vaccine^a	Mean PPRV titre in nasopharynx (log₁₀TCDI₅₀/mL)^b
Ad-GFP + Ad-IL-2 + Ad-GMCSF	3.88 +/- 0.84 (4/4)^c
Ad-H + Ad-GFP	< 0.1 (0/3)
Ad-H + Ad-IL-2	< 0.1 (0/3)
Ad-H + Ad-GMCSF	< 0.1 (0/3)
Ad-H + Ad-IL-2 + Ad-GMCSF	< 0.1 (0/3)

^aGoats were vaccinated as described in Table 1 and challenged with PPRV as described in Figure 3.
^bTitres of PPRV in nasal swabs on day 7 pc were analysed on SLAM-Vero cells and results expressed as the mean log₁₀ TCID₅₀/mL.
^cNumber of goats from which PPRV was isolated/total on day 7 pc.

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