Vaccination with Ad-H protects against PPRV challenge. Goats were vaccinated as described in Table 1 and challenged with PPRV as described in Figure 4. Mock refers to group A of Table 1 (GFP + IL-2 + GMCSF), while H++ refers to group E of Table 1 (H + IL-2 + GMCSF). (A) Changes in the number of blood leukocytes were determined daily after challenge and results are expressed as a % of day 0 value ± S.E. (B) Rectal temperatures were obtained daily and expressed mean body temperature ± S.E. (C) Signs of clinical disease were assessed daily and animals given a score based on the severity of congestion in the mucosa of the eyes, nose and gums, ocular and nasal discharge, temperature, diarrhoea, necrotic stomatitis and general malaise. Results are expressed as the mean score ± S.E. (D) Viremia was determined by qPCR and expressed as the mean 40 - ct value ± S.E.