Table 1 Experimental DNA vaccines and their protection in fish following experimental infection

IHNV

IHNV-G plus suicidal gene

Rainbow trout

I.m/none

Yes

[26]

IHNV

IHNV-G; different genogroups

Rainbow trout

I.m/none

Yes; cross-protection

[27]

IHNV

IHNV-G

Rainbow trout

Oral/PLGA

No

[28]

VHSV

E. tarda as delivery vehicle of the vaccine

Olive/Japanese flounder (Paralichthys olivaceus)

I.m

Yes

[29]

IPNV

VP2

Oral/alginate

Yes

[30]

IPNV

VP2; Segment A of TA strain

Atlantic salmon

I.m

No

[31]

SAV

E1 and E2

Atlantic salmon

I.m

No

[32]

Megalocytivirus

86-residue VP

Turbot (Scophthalmus maximus)

I.m

Yes

[33]

Edwardsiella tarda

Eta6-FliC chimeric protein

Japanese flounder (Paralichthys olivaceus)

I.m

Yes

[34]

E. tarda

D15-like surface antigen

Japanese flounder

I.m

Yes

[35]

E. tarda

Eta2

Japanese flounder

i.m

Yes

[36]

Streptococcus iniae

sagF, sagG and sagI

Japanese flounder

I.m

Yes

[37]

S. iniae

Sia10 delivered by E. tarda

Japanese flounder

Oral/alginate, immersion- boosted

Yes

[38]

Vibrio harveyi

FlaA

Yellow grouper (Epinephelus awoara)

I.m

Yes

[39]

V. harveyi

DegQ or/and Vhp1

Japanese flounder

I.m

Yes

[40]

V. alginolyticus

FlaA

Red snapper (Lutjanus campechanus)

I.m

Yes

[41]

S. iniae and V. anguillarum

Sia10 and/or OmpU

Turbot

I.m

Yes, cross-protection

[37]

Flavobacterium psychrophilum

Hsp60, hsp70

Rainbow trout

I.m

No

[42]

Cryptocaryon irritans

iAg

Orange spotted grouper (E. coioides)

I.m

Yes

[43]

Cryptobia salmocitica

Metalloprotease

Atlantic salmon and rainbow trout

I.m

Partly

[44]

Ichthyophthrius multifiliis

Immunobilization antigens and cystein protease

Rainbow trout

I.m, gene gun and air pressure

No

[45]