| |
Bone marrow
|
Peripheral blood
|
|---|
| |
Control
|
APP-infected
|
Control
|
APP-infected
|
|---|
|
CCR1
|
0.87
|
±
|
0.12 *
|
0.47
|
±
|
0.07 *
|
0.87
|
±
|
0.13
|
1.09
|
±
|
0.30
|
|
CCR2
|
0.35
|
±
|
0.07 *
|
0.18
|
±
|
0.02 *
|
0.23
|
±
|
0.08
|
0.11
|
±
|
0.03
|
|
CCR3
|
4.42
|
±
|
1.00 *†
|
1.86
|
±
|
0.62 *‡
|
18.79
|
±
|
4.77 †
|
9.21
|
±
|
4.28 ‡
|
|
CCR4
|
3.24
|
±
|
0.71 *†
|
1.33
|
±
|
0.41 *‡
|
13.44
|
±
|
3.25 †
|
6.42
|
±
|
3.00 ‡
|
|
CCR5
|
0.16
|
±
|
0.03 *
|
0.06
|
±
|
0.01 *‡
|
0.30
|
±
|
0.05
|
0.15
|
±
|
0.05 ‡
|
|
CCR6
|
n.d.
|
n.d.
|
n.d.
|
n.d.
|
|
CCR7
|
0.46
|
±
|
0.12 †
|
0.26
|
±
|
0.05
|
0.88
|
±
|
0.17 0†
|
0.24
|
±
|
0.10 0
|
|
CCR9
|
0.003
|
±
|
0.001
|
0.001
|
±
|
0.000
|
0.006
|
±
|
0.002 0
|
0.001
|
±
|
0.000 0
|
|
CCR10
|
2.62
|
±
|
0.54 *†
|
1.09
|
±
|
0.31 *‡
|
10.54
|
±
|
2.26 0†
|
4.86
|
±
|
2.00 0‡
|
|
CXCR3
|
2.55
|
±
|
0.55 *†
|
1.00
|
±
|
0.29 *‡
|
10.83
|
±
|
2.58 †
|
5.10
|
±
|
2.27 ‡
|
|
CXCR4
|
3.81
|
±
|
0.38 *†
|
2.04
|
±
|
0.15 *‡
|
8.70
|
±
|
0.68 †
|
9.05
|
±
|
1.82 ‡
|
|
CXCR6
|
0.002
|
±
|
0.001 *†
|
0.000
|
±
|
0.000 *
|
0.019
|
±
|
0.008 0†
|
0.001
|
±
|
0.000 0
|
|
CX3CR1
|
2.96
|
±
|
0.63 †
|
1.18
|
±
|
0.31 ‡
|
13.01
|
±
|
3.05 †
|
6.33
|
±
|
2.33 ‡
|
|
CD62L
|
0.81
|
±
|
0.20
|
0.86
|
±
|
0.21
|
0.77
|
±
|
0.32
|
1.29
|
±
|
0.27
|
|
CD163
|
5.31
|
±
|
0.52 *†
|
9.08
|
±
|
2.27 *‡
|
11.98
|
±
|
2.55 †
|
19.40
|
±
|
2.43 ‡
|
|
SLA-DR
|
16.62
|
±
|
2.77 *†
|
4.43
|
±
|
0.76 *
|
40.60
|
±
|
4.04 0†
|
4.23
|
±
|
1.23 0
|
|
TBP1
|
0.06
|
±
|
0.01
|
0.06
|
±
|
0.01
|
0.09
|
±
|
0.02
|
0.11
|
±
|
0.02
|
- The data are shown as a fold change of chemokine receptor, CD62L, CD163, SLA-DR and TBP1 reference gene mRNA expression in relation to the reference gene HPRT as measured by the RT-qPCR. Data are expressed as mean ± S.E.M. (n = 5). The significant differences (Mann-Whitey U test, P < 0.05,) between control and APP-infected pigs are marked with * (bone marrow) or 0 (peripheral blood). The significant differences (Mann–Whitney U test, P < 0.05) between bone marrow and peripheral blood monocytes are marked with † (control) or ‡ (APP-infected). The values which were elevated between control and APP-infected pigs are highlighted in bold. N.d, non-detected.
