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Table 3 Chemokine expression in various organs from control and APP-infected pigs.

From: Distribution of porcine monocytes in different lymphoid tissues and the lungs during experimental Actinobacillus pleuropneumoniae infection and the role of chemokines

 

Bone marrow

Lungs

Tracheobronchial LN

Control

APP-infected

Control

APP-infected

Control

APP-infected

 

Unaffected area

Demarcation zone

Necrotic area

 

CCL1

0.028

±

0.018

0.050

±

0.037

0.025

±

0.006

0.013

±

0.002

0.008

±

0.002*

0.152

±

0.055*

0.009

±

0.001

0.007

±

0.001

CCL2

0.195

±

0.043

0.486

±

0.183

1.799

±

0.291

2.027

±

0.394

2.785

±

0.831

101.809

±

25.084**

3.831

±

0.228

5.296

±

1.162

CCL3

0.117

±

0.015

0.174

±

0.026*

0.623

±

0.121

2.149

±

0.497**

1.521

±

0.313*

148.299

±

48.339**

0.240

±

0.057

1.169

±

0.307**

CCL4

0.103

±

0.017

0.148

±

0.024

0.805

±

0.108

2.006

±

0.451*

1.506

±

0.458

57.529

±

15.897**

0.291

±

0.057

0.922

±

0.158**

CCL5

0.015

±

0.014

0.054

±

0.000

2.610

±

0.455

2.015

±

0.322

1.259

±

0.210

11.351

±

1.899**

2.293

±

0.481

1.540

±

0.179

CCL8

0.099

±

0.013

0.158

±

0.024*

0.121

±

0.023

0.110

±

0.016

0.125

±

0.012

0.428

±

0.153

0.336

±

0.080

0.380

±

0.038

CCL11

0.003

±

0.001

0.001

±

0.000

0.002

±

0.001

0.004

±

0.002

0.007

±

0.003

0.132

±

0.032**

0.002

±

0.001

0.006

±

0.004

CCL17

0.000

±

0.000

0.001

±

0.000

0.033

±

0.012

0.025

±

0.006

0.021

±

0.005

0.120

±

0.031

0.715

±

0.085

0.430

±

0.080*

CCL19

0.183

±

0.039

1.478

±

0.690**

1.526

±

0.097

3.689

±

0.540**

3.813

±

0.728*

39.163

±

9.875**

45.957

±

4.607

77.840

±

7.874*

CCL20

0.000

±

0.000

0.001

±

0.000

0.009

±

0.002

0.010

±

0.002

0.019

±

0.003

6.833

±

1.846**

0.288

±

0.046

0.736

±

0.217

CCL21

0.016

±

0.008

0.006

±

0.001

0.976

±

0.107

1.053

±

0.166

1.147

±

0.189

0.533

±

0.138*

17.522

±

2.483

6.464

±

2.130**

CCL22

0.003

±

0.001

0.002

±

0.001

0.038

±

0.013

0.024

±

0.006

0.024

±

0.004

0.153

±

0.040*

0.673

±

0.124

0.306

±

0.049*

CCL25

0.007

±

0.001

0.006

±

0.001

0.013

±

0.001

0.011

±

0.001

0.013

±

0.001

0.011

±

0.001

0.010

±

0.001

0.006

±

0.001**

CCL27

0.000

±

0.000

0.001

±

0.000

0.002

±

0.000

0.003

±

0.000

0.002

±

0.000

0.005

±

0.002

0.001

±

0.000

0.001

±

0.000

CCL28

n.d.

n.d.

0.036

±

0.003

0.038

±

0.013

0.045

±

0.032

0.011

±

0.003**

n.d.

n.d.

CXCL9

0.180

±

0.026

0.141

±

0.018

1.704

±

0.180

1.186

±

0.288

0.820

±

0.197*

1.644

±

0.740

4.188

±

0.591

1.790

±

0.225**

CXCL10

0.983

±

0.222

0.996

±

0.197

5.272

±

0.425

3.685

±

0.742

2.788

±

0.545*

8.892

±

4.605

6.644

±

0.826

3.097

±

0.531**

CXCL11

0.353

±

0.209

0.036

±

0.013

0.124

±

0.037

0.072

±

0.023

0.059

±

0.017

0.457

±

0.201

0.146

±

0.038

0.030

±

0.007**

CXCL12

1.061

±

0.123

1.022

±

0.224

0.378

±

0.047

0.241

±

0.034*

0.246

±

0.040

0.453

±

0.081

6.123

±

0.842

2.024

±

0.580**

CXCL14

0.794

±

0.075

1.376

±

0.322

1.935

±

0.241

2.553

±

0.381

4.312

±

0.547*

35.412

±

4.900**

2.961

±

0.400

5.579

±

0.586**

CXCL16

0.605

±

0.058

0.372

±

0.036*

3.371

±

0.211

2.340

±

0.106**

2.639

±

0.343*

9.151

±

0.881**

1.427

±

0.092

2.510

±

0.486**

CX3CL1

0.010

±

0.004

0.025

±

0.006

0.078

±

0.017

0.044

±

0.011

0.050

±

0.010

0.639

±

0.225*

0.106

±

0.008

0.048

±

0.016*

  1. The data are shown as a fold change of chemokine mRNA expression in relation to the reference gene HPRT as measured by the RT-qPCR. Data are expressed as mean ± S.E.M. (Control: n = 6, APP-infected: n = 9). The significant differences (Mann–Whitney U test) between control and APP-infected pigs are marked with *P < 0.05, **P < 0.01. The values which were elevated between control and APP-infected pigs are highlighted in bold. LN, lymph node, n.d, non-detected.