Bone marrow | Lungs | Tracheobronchial LN | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Control | APP-infected | Control | APP-infected | Control | APP-infected | |||||||||||||||||||
Unaffected area | Demarcation zone | Necrotic area | ||||||||||||||||||||||
CCL1 | 0.028 | ± | 0.018 | 0.050 | ± | 0.037 | 0.025 | ± | 0.006 | 0.013 | ± | 0.002 | 0.008 | ± | 0.002* | 0.152 | ± | 0.055* | 0.009 | ± | 0.001 | 0.007 | ± | 0.001 |
CCL2 | 0.195 | ± | 0.043 | 0.486 | ± | 0.183 | 1.799 | ± | 0.291 | 2.027 | ± | 0.394 | 2.785 | ± | 0.831 | 101.809 | ± | 25.084** | 3.831 | ± | 0.228 | 5.296 | ± | 1.162 |
CCL3 | 0.117 | ± | 0.015 | 0.174 | ± | 0.026* | 0.623 | ± | 0.121 | 2.149 | ± | 0.497** | 1.521 | ± | 0.313* | 148.299 | ± | 48.339** | 0.240 | ± | 0.057 | 1.169 | ± | 0.307** |
CCL4 | 0.103 | ± | 0.017 | 0.148 | ± | 0.024 | 0.805 | ± | 0.108 | 2.006 | ± | 0.451* | 1.506 | ± | 0.458 | 57.529 | ± | 15.897** | 0.291 | ± | 0.057 | 0.922 | ± | 0.158** |
CCL5 | 0.015 | ± | 0.014 | 0.054 | ± | 0.000 | 2.610 | ± | 0.455 | 2.015 | ± | 0.322 | 1.259 | ± | 0.210 | 11.351 | ± | 1.899** | 2.293 | ± | 0.481 | 1.540 | ± | 0.179 |
CCL8 | 0.099 | ± | 0.013 | 0.158 | ± | 0.024* | 0.121 | ± | 0.023 | 0.110 | ± | 0.016 | 0.125 | ± | 0.012 | 0.428 | ± | 0.153 | 0.336 | ± | 0.080 | 0.380 | ± | 0.038 |
CCL11 | 0.003 | ± | 0.001 | 0.001 | ± | 0.000 | 0.002 | ± | 0.001 | 0.004 | ± | 0.002 | 0.007 | ± | 0.003 | 0.132 | ± | 0.032** | 0.002 | ± | 0.001 | 0.006 | ± | 0.004 |
CCL17 | 0.000 | ± | 0.000 | 0.001 | ± | 0.000 | 0.033 | ± | 0.012 | 0.025 | ± | 0.006 | 0.021 | ± | 0.005 | 0.120 | ± | 0.031 | 0.715 | ± | 0.085 | 0.430 | ± | 0.080* |
CCL19 | 0.183 | ± | 0.039 | 1.478 | ± | 0.690** | 1.526 | ± | 0.097 | 3.689 | ± | 0.540** | 3.813 | ± | 0.728* | 39.163 | ± | 9.875** | 45.957 | ± | 4.607 | 77.840 | ± | 7.874* |
CCL20 | 0.000 | ± | 0.000 | 0.001 | ± | 0.000 | 0.009 | ± | 0.002 | 0.010 | ± | 0.002 | 0.019 | ± | 0.003 | 6.833 | ± | 1.846** | 0.288 | ± | 0.046 | 0.736 | ± | 0.217 |
CCL21 | 0.016 | ± | 0.008 | 0.006 | ± | 0.001 | 0.976 | ± | 0.107 | 1.053 | ± | 0.166 | 1.147 | ± | 0.189 | 0.533 | ± | 0.138* | 17.522 | ± | 2.483 | 6.464 | ± | 2.130** |
CCL22 | 0.003 | ± | 0.001 | 0.002 | ± | 0.001 | 0.038 | ± | 0.013 | 0.024 | ± | 0.006 | 0.024 | ± | 0.004 | 0.153 | ± | 0.040* | 0.673 | ± | 0.124 | 0.306 | ± | 0.049* |
CCL25 | 0.007 | ± | 0.001 | 0.006 | ± | 0.001 | 0.013 | ± | 0.001 | 0.011 | ± | 0.001 | 0.013 | ± | 0.001 | 0.011 | ± | 0.001 | 0.010 | ± | 0.001 | 0.006 | ± | 0.001** |
CCL27 | 0.000 | ± | 0.000 | 0.001 | ± | 0.000 | 0.002 | ± | 0.000 | 0.003 | ± | 0.000 | 0.002 | ± | 0.000 | 0.005 | ± | 0.002 | 0.001 | ± | 0.000 | 0.001 | ± | 0.000 |
CCL28 | n.d. | n.d. | 0.036 | ± | 0.003 | 0.038 | ± | 0.013 | 0.045 | ± | 0.032 | 0.011 | ± | 0.003** | n.d. | n.d. | ||||||||
CXCL9 | 0.180 | ± | 0.026 | 0.141 | ± | 0.018 | 1.704 | ± | 0.180 | 1.186 | ± | 0.288 | 0.820 | ± | 0.197* | 1.644 | ± | 0.740 | 4.188 | ± | 0.591 | 1.790 | ± | 0.225** |
CXCL10 | 0.983 | ± | 0.222 | 0.996 | ± | 0.197 | 5.272 | ± | 0.425 | 3.685 | ± | 0.742 | 2.788 | ± | 0.545* | 8.892 | ± | 4.605 | 6.644 | ± | 0.826 | 3.097 | ± | 0.531** |
CXCL11 | 0.353 | ± | 0.209 | 0.036 | ± | 0.013 | 0.124 | ± | 0.037 | 0.072 | ± | 0.023 | 0.059 | ± | 0.017 | 0.457 | ± | 0.201 | 0.146 | ± | 0.038 | 0.030 | ± | 0.007** |
CXCL12 | 1.061 | ± | 0.123 | 1.022 | ± | 0.224 | 0.378 | ± | 0.047 | 0.241 | ± | 0.034* | 0.246 | ± | 0.040 | 0.453 | ± | 0.081 | 6.123 | ± | 0.842 | 2.024 | ± | 0.580** |
CXCL14 | 0.794 | ± | 0.075 | 1.376 | ± | 0.322 | 1.935 | ± | 0.241 | 2.553 | ± | 0.381 | 4.312 | ± | 0.547* | 35.412 | ± | 4.900** | 2.961 | ± | 0.400 | 5.579 | ± | 0.586** |
CXCL16 | 0.605 | ± | 0.058 | 0.372 | ± | 0.036* | 3.371 | ± | 0.211 | 2.340 | ± | 0.106** | 2.639 | ± | 0.343* | 9.151 | ± | 0.881** | 1.427 | ± | 0.092 | 2.510 | ± | 0.486** |
CX3CL1 | 0.010 | ± | 0.004 | 0.025 | ± | 0.006 | 0.078 | ± | 0.017 | 0.044 | ± | 0.011 | 0.050 | ± | 0.010 | 0.639 | ± | 0.225* | 0.106 | ± | 0.008 | 0.048 | ± | 0.016* |