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Table 3 Chemokine expression in various organs from control and APP-infected pigs.

From: Distribution of porcine monocytes in different lymphoid tissues and the lungs during experimental Actinobacillus pleuropneumoniae infection and the role of chemokines

  Bone marrow Lungs Tracheobronchial LN
Control APP-infected Control APP-infected Control APP-infected
  Unaffected area Demarcation zone Necrotic area  
CCL1 0.028 ± 0.018 0.050 ± 0.037 0.025 ± 0.006 0.013 ± 0.002 0.008 ± 0.002* 0.152 ± 0.055* 0.009 ± 0.001 0.007 ± 0.001
CCL2 0.195 ± 0.043 0.486 ± 0.183 1.799 ± 0.291 2.027 ± 0.394 2.785 ± 0.831 101.809 ± 25.084** 3.831 ± 0.228 5.296 ± 1.162
CCL3 0.117 ± 0.015 0.174 ± 0.026* 0.623 ± 0.121 2.149 ± 0.497** 1.521 ± 0.313* 148.299 ± 48.339** 0.240 ± 0.057 1.169 ± 0.307**
CCL4 0.103 ± 0.017 0.148 ± 0.024 0.805 ± 0.108 2.006 ± 0.451* 1.506 ± 0.458 57.529 ± 15.897** 0.291 ± 0.057 0.922 ± 0.158**
CCL5 0.015 ± 0.014 0.054 ± 0.000 2.610 ± 0.455 2.015 ± 0.322 1.259 ± 0.210 11.351 ± 1.899** 2.293 ± 0.481 1.540 ± 0.179
CCL8 0.099 ± 0.013 0.158 ± 0.024* 0.121 ± 0.023 0.110 ± 0.016 0.125 ± 0.012 0.428 ± 0.153 0.336 ± 0.080 0.380 ± 0.038
CCL11 0.003 ± 0.001 0.001 ± 0.000 0.002 ± 0.001 0.004 ± 0.002 0.007 ± 0.003 0.132 ± 0.032** 0.002 ± 0.001 0.006 ± 0.004
CCL17 0.000 ± 0.000 0.001 ± 0.000 0.033 ± 0.012 0.025 ± 0.006 0.021 ± 0.005 0.120 ± 0.031 0.715 ± 0.085 0.430 ± 0.080*
CCL19 0.183 ± 0.039 1.478 ± 0.690** 1.526 ± 0.097 3.689 ± 0.540** 3.813 ± 0.728* 39.163 ± 9.875** 45.957 ± 4.607 77.840 ± 7.874*
CCL20 0.000 ± 0.000 0.001 ± 0.000 0.009 ± 0.002 0.010 ± 0.002 0.019 ± 0.003 6.833 ± 1.846** 0.288 ± 0.046 0.736 ± 0.217
CCL21 0.016 ± 0.008 0.006 ± 0.001 0.976 ± 0.107 1.053 ± 0.166 1.147 ± 0.189 0.533 ± 0.138* 17.522 ± 2.483 6.464 ± 2.130**
CCL22 0.003 ± 0.001 0.002 ± 0.001 0.038 ± 0.013 0.024 ± 0.006 0.024 ± 0.004 0.153 ± 0.040* 0.673 ± 0.124 0.306 ± 0.049*
CCL25 0.007 ± 0.001 0.006 ± 0.001 0.013 ± 0.001 0.011 ± 0.001 0.013 ± 0.001 0.011 ± 0.001 0.010 ± 0.001 0.006 ± 0.001**
CCL27 0.000 ± 0.000 0.001 ± 0.000 0.002 ± 0.000 0.003 ± 0.000 0.002 ± 0.000 0.005 ± 0.002 0.001 ± 0.000 0.001 ± 0.000
CCL28 n.d. n.d. 0.036 ± 0.003 0.038 ± 0.013 0.045 ± 0.032 0.011 ± 0.003** n.d. n.d.
CXCL9 0.180 ± 0.026 0.141 ± 0.018 1.704 ± 0.180 1.186 ± 0.288 0.820 ± 0.197* 1.644 ± 0.740 4.188 ± 0.591 1.790 ± 0.225**
CXCL10 0.983 ± 0.222 0.996 ± 0.197 5.272 ± 0.425 3.685 ± 0.742 2.788 ± 0.545* 8.892 ± 4.605 6.644 ± 0.826 3.097 ± 0.531**
CXCL11 0.353 ± 0.209 0.036 ± 0.013 0.124 ± 0.037 0.072 ± 0.023 0.059 ± 0.017 0.457 ± 0.201 0.146 ± 0.038 0.030 ± 0.007**
CXCL12 1.061 ± 0.123 1.022 ± 0.224 0.378 ± 0.047 0.241 ± 0.034* 0.246 ± 0.040 0.453 ± 0.081 6.123 ± 0.842 2.024 ± 0.580**
CXCL14 0.794 ± 0.075 1.376 ± 0.322 1.935 ± 0.241 2.553 ± 0.381 4.312 ± 0.547* 35.412 ± 4.900** 2.961 ± 0.400 5.579 ± 0.586**
CXCL16 0.605 ± 0.058 0.372 ± 0.036* 3.371 ± 0.211 2.340 ± 0.106** 2.639 ± 0.343* 9.151 ± 0.881** 1.427 ± 0.092 2.510 ± 0.486**
CX3CL1 0.010 ± 0.004 0.025 ± 0.006 0.078 ± 0.017 0.044 ± 0.011 0.050 ± 0.010 0.639 ± 0.225* 0.106 ± 0.008 0.048 ± 0.016*
  1. The data are shown as a fold change of chemokine mRNA expression in relation to the reference gene HPRT as measured by the RT-qPCR. Data are expressed as mean ± S.E.M. (Control: n = 6, APP-infected: n = 9). The significant differences (Mann–Whitney U test) between control and APP-infected pigs are marked with *P < 0.05, **P < 0.01. The values which were elevated between control and APP-infected pigs are highlighted in bold. LN, lymph node, n.d, non-detected.
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Veterinary Research

ISSN: 1297-9716