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Figure 5 | Veterinary Research

Figure 5

From: Different virulence of porcine and porcine-like bovine rotavirus strains with genetically nearly identical genomes in piglets and calves

Figure 5

Extra-intestinal histopathological changes and distribution of antigen-positive cells in piglets infected with bovine G5P[7] RVA strain K5. (A-C) Compared to densely packed lymphocytes (asterisk) in the cortex of normal mesenteric lymph node (MLN) from a mock-inoculated piglet (A), MLN from a virus-inoculated piglet showed lymphoid cell depletion (asterisk) in the cortex (B) and RVA antigen-positive cells (arrows) (C). (D-F) The lung sampled from a mock-inoculated piglet reveals normal thin alveolar wall (arrows) (D), whereas the lung sampled from a virus-inoculated piglet shows interstitial pneumonia (arrows) (E) and an RVA antigen-positive reaction in the pneumocyte (arrowhead) and lymphoid cell (arrow) (F). (G-I) Compared to normal fat-storing hepatocytes (arrows) from a mock-inoculated piglet (G), liver sampled from a virus-inoculated piglet shows multiple scattered necrotic hepatocytes (arrows) (H) and RVA antigen-positive cells (arrows) (I). (J-L) Choroid plexus sampled from a mock-inoculated piglet had intact epithelium (arrowheads) (J), whereas choroid plexus sampled from a virus-inoculated piglet displayed epithelial degeneration (arrowheads) and necrosis (arrows), and lymphoid cell infiltration (double arrow) into the tela choroidea (H), and RVA antigen-positive cells (arrow) (L). Hematoxylin and eosin stain (A, B, D, E, G, H, J, and K). Indirect immunofluorescence assay with monoclonal antibody against the VP6 protein of strain OSU (C, F, I, and L). Bars denote 100 μm.

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