SRLV replication in polarized macrophages. MDM were exposed for 6 days to the cytokines IFN-γ, IL-4, or pN3 (non-stimulated control), and subsequently infected with different SRLV strains: EV1 (empty bars), 496 (full bars), CAEV-Cork (grey bars) CAEV-To (light grey bars), Roccaverano (horizontal-lined bars) and Seui (vertical-lined bars). RT activity was measured (A450nm) in clarified supernatants at 7 days post infection. The values are the median (± interquartile range) of at least 3 independent experiments. * p < 0.05 (paired Wilcoxon Rank Sum test).