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Table 3 Fluctuation analysis for the calculation of the mutation frequencies and rates for H. bizzozeronii CIII-1 GEN which becomes resistant to metronidazole

From: Contingency nature of Helicobacter bizzozeronii oxygen-insensitive NAD(P)H-nitroreductase (HBZC1_00960) and its role in metronidazole resistance

Experiment No. of cells per culture (Nt) Fraction of culture plated (z) Resistant bacteria Mutation rate (μ) Mutation frequency (f)
    mean mobs mact   
1 2.18 × 107 0.08 87 22.872 104.44 4.78 × 10-6 4.96 × 10-5
2 1.07 × 108 0.08 > 300 ND ND ND ND
3 1.40 × 107 0.08 > 300 ND ND ND ND
4 1.30 × 107 0.02 62 18.099 226.70 1.74 × 10-5 2.38 × 10-4
  1. There are 21 independent cultures for each experiment.