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Table 3 Fluctuation analysis for the calculation of the mutation frequencies and rates for H. bizzozeronii CIII-1 GEN which becomes resistant to metronidazole

From: Contingency nature of Helicobacter bizzozeronii oxygen-insensitive NAD(P)H-nitroreductase (HBZC1_00960) and its role in metronidazole resistance

Experiment

No. of cells per culture (Nt)

Fraction of culture plated (z)

Resistant bacteria

Mutation rate (μ)

Mutation frequency (f)

   

mean

mobs

mact

  

1

2.18 × 107

0.08

87

22.872

104.44

4.78 × 10-6

4.96 × 10-5

2

1.07 × 108

0.08

> 300

ND

ND

ND

ND

3

1.40 × 107

0.08

> 300

ND

ND

ND

ND

4

1.30 × 107

0.02

62

18.099

226.70

1.74 × 10-5

2.38 × 10-4

  1. There are 21 independent cultures for each experiment.
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Veterinary Research

ISSN: 1297-9716