Contingency nature of Helicobacter bizzozeronii oxygen-insensitive NAD(P)H-nitroreductase (HBZC1_00960) and its role in metronidazole resistance

Table 2 MIC values of metronidazole after 4 days of incubation for H. bizzozeronii strain CIII-1 ^GEN , H. bizzozeronii CCUG 35545 ^T , and corresponding mutants

*H. bizzozeronii* strains	Cytosine stretch in 3′ of *rdxA*	Mutation	MIC value (μg/mL)
CIII-1^GEN	C₈		4
CIII-1^GEN M1	C₉		32
CIII-1^GEN M2	C₉		32
CIII-1^GEN M3	C₉		32
CIII-1^GEN M4	C₉		32
CIII-1^GEN M5	C₉		32
CIII-1^GEN M6	C₉		32
CIII-1^GEN M7	C₉		32
CIII-1^GEN M8	C₉		32
CIII-1^GEN M9	C₈	A₁₈₈→.	32
CIII-1^GEN M10	C₉		32
CIII-1^GEN M11	C₉		32
CIII-1^GEN C1	C₈	rdxA::cat	32
CIII-1^GEN C2	C₈	rdxA::cat	32
CCUG 35545^T	NS*		8
CCUG 35545^T S1	NS	rdxA::cat	64
CCUG 35545^T S2	NS	rdxA::cat	64

The length of the 3′ SSCR and mutations in rdxA are indicated for each strain.
*NS: not sequenced.

ISSN: 1297-9716