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Table 2 MIC values of metronidazole after 4 days of incubation for H. bizzozeronii strain CIII-1 GEN , H. bizzozeronii CCUG 35545 T , and corresponding mutants

From: Contingency nature of Helicobacter bizzozeronii oxygen-insensitive NAD(P)H-nitroreductase (HBZC1_00960) and its role in metronidazole resistance

H. bizzozeronii strains Cytosine stretch in 3′ of rdxA Mutation MIC value (μg/mL)
CIII-1GEN C8   4
CIII-1GEN M1 C9   32
CIII-1GEN M2 C9   32
CIII-1GEN M3 C9   32
CIII-1GEN M4 C9   32
CIII-1GEN M5 C9   32
CIII-1GEN M6 C9   32
CIII-1GEN M7 C9   32
CIII-1GEN M8 C9   32
CIII-1GEN M9 C8 A188→. 32
CIII-1GEN M10 C9   32
CIII-1GEN M11 C9   32
CIII-1GEN C1 C8 rdxA::cat 32
CIII-1GEN C2 C8 rdxA::cat 32
CCUG 35545T NS*   8
CCUG 35545T S1 NS rdxA::cat 64
CCUG 35545T S2 NS rdxA::cat 64
  1. The length of the 3′ SSCR and mutations in rdxA are indicated for each strain.
  2. *NS: not sequenced.