The non-pathogenic Australian rabbit calicivirus RCV-A1 provides temporal and partial cross protection to lethal Rabbit Haemorrhagic Disease Virus infection which is not dependent on antibody titres

Table 3 Summary of experiments assessing the level of cross protection to lethal RHDV infection provided by RCV-A1

Study No.	Protection rate	N	RCV-A1 infection	Time post RCV-A1 infection	RHDV challenge	Reference
1	52%	11/21	Natural infection	Unknown	One dose 1000 LD ₅₀, IM	[14]
2	36%	22/61	Natural infection	Unknown	One dose 1500 LD ₅₀, PO	[15]
3	33%	25/77	Natural infection	Unknown	One dose 1500 LD ₅₀₀, PO	[29]
4	50%	2/4	Experimental infection	4 weeks	One dose 500 LD ₅₀, PO	[19]
5a	38%	3/8	Natural infection	< 8 weeks	One dose 500 LD ₅₀, PO and/or continuous exposure (contaminated environment)	This report
5b	13%	1/8	Natural infection	8 - 10 weeks	One dose 500 LD ₅₀, PO and/or continuous exposure (contaminated environment)	This report
5c	6%	1/18	Natural infection	> 10 weeks	One dose 500 LD ₅₀, PO and/or continuous exposure (contaminated environment)	This report

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