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Table 1 Experimental groups, mortality rates, survival times and fever responses of the 46 rabbits subjected to RHDV challenge following previous RCV-A1 exposure

From: The non-pathogenic Australian rabbit calicivirus RCV-A1 provides temporal and partial cross protection to lethal Rabbit Haemorrhagic Disease Virus infection which is not dependent on antibody titres

ID

Sex

Inoculation

Survival

Survival time [d]

Adjusted survival time [d]*

Fever**

Duration of fever [h] ***

Group 1

       

< 8 weeks between RCV-A1 and RHDV infection

   

18

m

infected

Y

  

Y

 

11

f

contact

Y

  

N

 

40

f

contact

Y

  

Y

 

7

m

infected

N

8.8

 

Y

41.0

29

m

infected

N

9.9

 

Y

5.0

31

f

infected

N

2.6

 

N

 

37

m

infected

N

11.4

 

Y

15.0

36

m

contact

N

12.2

9.8

Y

13.0

Group 2

       

8-10 weeks between RCV-A1 and RHDV infection

   

25

f

contact

Y

  

Y

 

20

F

infected

N

10.5

 

Y

14.0

38

m

infected

N

8.5

 

N

 

50

f

infected

N

4.5

 

Y

14.5

28

m

contact

N

10.4

8.0

Y

15.0

39

m

contact

N

12.2

9.8

Y

4.5

44

f

contact

N

9.9

7.5

Y

15.0

47

f

contact

N

7.0

4.6

Y

22.0

Group 3

       

>10 weeks between RCV-A1 and RHDV infection

   

32

f

infected

Y

  

Y

 

2

f

infected

N

4.5

 

Y

14.5

3

f

infected

N

3.4

 

Y

2.3

4

f

infected

N

2.6

 

Y

7.5

6

m

infected

N

7.4

 

Y

16.0

12

f

infected

N

4.4

 

Y

5.3

15

f

infected

N

4.6

 

Y

15.8

16

m

infected

N

7.3

 

Y

14.0

17

m

infected

N

8.3

 

Y

6.5

19

m

infected

N

3.2

 

Y

3.5

21

f

infected

N

2.5

 

Y

14.0

24

f

infected

N

2.2

 

N

 

8

m

contact

N

7.0

4.6

Y

5.0

23

f

contact

N

6.1

3.7

Y

4.5

26

m

contact

N

6.2

3.8

Y

9.0

27

m

contact

N

9.3

6.9

Y

12.0

33

f

contact

N

11.0

8.6

N

 

45

f

contact

N

4.2

1.8

Y

6.5

Rabbits with unknown infection history

   

30

f

infected

Y

  

N

 

10

f

infected

N

6.2

 

Y

6.5

14

f

infected

N

2.8

 

Y

11.5

35

f

infected

N

9.5

 

Y

32.0

48

f

infected

N

9.7

 

Y

11.0

49

f

infected

N

4.0

 

Y

3.0

1

f

contact

N

7.8

5.4

Y

12.0

5

f

contact

N

7.7

5.3

Y

9.5

34

f

contact

N

15.8

13.4

N

 

42

f

contact

N

6.7

4.3

Y

9.5

43

f

contact

N

4.7

2.3

N

 

46

f

contact

N

5.2

2.8

Y

5.0

  1. Surviving animals are shown in bold italics.
  2. *Adjusted survival time is −2.4 days for the contact infected animals.
  3. ** Temperature >40.5°C. *** Time between recorded onset of fever and death.