FMDV-specific immune responses in pigs. Groups of pigs (n = 5) immunized with inactivated FMDV or FMD VLP, including three PBS-inoculated pigs as a control, by intramuscular injection. Blood samples were collected at 10 dpi, 18 dpi and 28 dpi after vaccination for virus-specific antibody response (A) and neutralizing antibody response (B). The titers of virus-specific antibody and neutralizing antibody were expressed by the average titers of pigs in one whole group at different time points. PMBC were isolated from all pigs at 28 dpi. IFN-γ secretion (C) by PMBC was measured and is shown as pg/mL. Statistical significance among groups was compared.