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Table 3 GLMM Onset of clinical signs

From: Understanding foot-and-mouth disease virus transmission biology: identification of the indicators of infectiousness

Variable Estimated effect se p odds 95% CI χ 2/DF
OPF VI       
>5.0 log10 TCID50/mL 1.918 0.791 0.020 6.81 1.38-33.6 1.01
<5.0 log10 TCID50/mL - -     
Onset OPF VI > CT       
yes 2.410 0.974 0.016 11.1 1.59-77.9 1.02
no - -     
OPF qRT-PCR       
>6.5 log10 copies/mL 2.670 1.021 0.013 14.4 1.83-114 0.99
<6.5 log10 copies/mL - -     
Onset OPF qRT-PCR > CT       
yes 2.254 0.916 0.017 9.53 1.53-59.4 1.02
no - -     
Blood VI       
>2.4 log10 TCID50/mL 2.681 0.867 0.004 14.6 2.53-84.4 1.11
<2.4 log10 TCID50/mL - -     
Appear -1D blood VI > 0       
yes 3.325 0.994 0.002 27.8 3.83-202 1.08
no - -     
Appear -2D blood VI > 0       
yes 1.990 0.938 0.038 7.31 1.12-47.6 1.08
no - -     
Onset blood VI > CT       
yes 2.503 0.953 0.011 12.2 1.82-82.0 1.15
no - -     
Onset -1D blood VI > CT       
yes 4.502 1.173 0.003 90.2 8.69-936 1.11
no - -     
Blood qRT-PCR       
>4.6 log10 copies/mL 3.122 1.063 0.005 22.7 2.67-193 1.02
<4.6 log10 copies/mL - -     
Appear -1D blood qRT-PCR > 0       
yes 3.325 0.994 0.001 27.8 3.83-202 1.08
no - -     
Onset blood qRT-PCR > CT       
yes 2.600 0.925 0.006 13.5 2.13-85.2 1.06
no - -     
Onset -1D blood qRT PCR > CT       
yes 3.212 1.038 0.003 24.8 3.12-197 1.12
no - -     
Nasal fluid VI       
>4 log10 TCID50/mL 1.829 0.777 0.023 6.23 1.31-29.7 1.03
<4 log10 TCID50/mL - -     
Appear of nasal fluid VI > 0       
yes 2.917 0.927 0.002 18.5 2.91-118 1.06
no - -     
Onset nasal fluid VI > CT       
yes 2.511 0.972 0.012 12.3 1.77-85.6 1.02
no - -     
Type 1 IFN       
>1IU/mL 1.575 0.762 0.044 4.83 1.04-22.4 1.03
<1IU/mL - -     
Onset Type 1 IFN > CT       
yes 4.06 1.092 0.0004 57.9 6.56-52.0 1.06
no - -     
  1. Estimated effects, odds ratios and 95% CI for significant (p<0.05) factors in the final generalised linear mixed models (GLMM). CT, estimated cut-off from ROC analysis. -1D/-2D represents appearance or onset of a given factor 1 or 2 days (D) prior.