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Table 7 Functional pathways of genes most affected by SaS stimulation, determined by using the Genomatix Pathway System (GePS)

From: Differential response of bovine mammary epithelial cells to Staphylococcus aureus or Escherichia coli agonists of the innate immune system

SaS vs Ref 3 h (List of 65 genes taken into account)   
  p value nb of genes
Signal transduction pathways (canonical)   
AP-1 transcription factor network 5.05 × 10-7 6/69
Signal transduction pathways (Genomatix)   
Interleukin 17A 8.75 × 10-7 7/137
Protein kinase B 1.59 × 10-6 9/297
Baculoviral IAP repeat containing protein, 1.94 × 10-6 9/304
apoptosis inhibitor   
FBJ murine osteosarcoma viral oncogene 6.49 × 10-6 4/32
homolog B   
Cyclin D1 7.69 × 10-6 10/461
Chemokine (CC motif) ligand 2 8.40 × 10-6 8/272
Molecular functions (GO)   
Too few genes, p value > 10-5   
Biological processes (GO)   
Too few genes, p value > 10-5   
SaS vs Ref 6 h (213 genes taken into account)   
Signal transduction pathways (canonical)   
Too few genes, p value > 10-5   
Signal transduction pathways (Genomatix)   
Minichromosome maintenance complex 6.13 × 10-7 7/42
Cyclin B1 9.29 × 10-7 10/112
Cyclin D1 2.34 × 10-6 19/461
DNA repair 4.43 × 10-6 23/725
Cyclin A2 4.37 × 10-6 11/167
Checkpoint 2.51 × 10-5 16/402
Interleukin 17A 4.07 × 10-5 10/137
Nuclear receptor subfamily 3, group C 4.08 × 10-5 10/171
Cell cycle 4.94 × 10-5 32/1309
Aryl hydrocarbon receptor 9.93 × 10-5 10/190
Molecular functions (GO)   
Protein binding 2.95 × 10-5 100/8067
Protein heterodimerizaton activity 1.23 × 10-4 9/202
Oxidoreductase activity 2.39 × 10-4 17/685
Biological processes (GO)   
Symbiosis, encompassing mutualism 2.15 × 10-5 6/58
Viral reproduction 3.84 × 10-5 7/94
Cell death 1.05 × 10-4 27/1275
Death 1.10 × 10-4 27/1279
Response to organic substance 1.24 × 10-4 21/874
Oxidation reduction 1.98 × 10-4 17/645