Table 6 Functional pathways of genes most affected by LPS stimulation, determined by using the Genomatix Pathway System (GePS)
LPS vs Ref 3Â h (List of 147 genes taken into account) | Â | Â |
|---|---|---|
| Â | p value | nb of genes* |
Signal transduction pathways (canonical) | Â | Â |
Fas signaling pathway | 7.58 × 10-6 | 5/20 |
Signal transduction pathways (Genomatix) | p value | nb of genes |
NF kappa B | 1.52 × 10-12 | 41/1542 |
Signal transducer and activator of transcription | 1.76 × 10-12 | 36/1184 |
Toll like receptor | 2.49 × 10-12 | 26/593 |
Apoptosis | 7.27 × 10-12 | 52/2592 |
Tumor protein p53 | 8.23 × 10-12 | 34/1108 |
Interleukin 1 | 2.05 × 10-11 | 27/706 |
Janus kinase | 2.57 × 10-11 | 26/657 |
Tumor necrosis factor | 5.10 × 10-11 | 34/1182 |
Interleukin 6 | 5.57 × 10-11 | 26/680 |
Inflammatory | 8.31 × 10-11 | 33/1133 |
Nuclotide oligodimerization domain/ | 9.52 × 10-11 | 13/131 |
Caspase recruitment protein family | Â | Â |
Molecular functions (GO) | Â | Â |
Cytokine receptor binding | 2.29 × 10-9 | 12/187 |
Receptor binding | 9.83 × 10-9 | 23/917 |
Cytokine activity | 5.22 × 10-8 | 11/199 |
Chemokine activity | 4.88 × 10-7 | 6/47 |
Chemokine receptor binding | 9.02 × 10-7 | 6/52 |
Biological processes (GO) | Â | Â |
Immune system process | 2.27 × 10-11 | 28/1094 |
Immune response | 2.98 × 10-10 | 22/736 |
Locomotion | 2.72 × 10-9 | 19/605 |
Multi-organism process | 8.37 × 10-9 | 21/800 |
Response to chemical stimulus | 1.67 × 10-8 | 28/1461 |
LPS vs Ref 6Â h (List of 193 genes taken into account) | Â | Â |
Signal transduction pathways (Genomatix) | Â | Â |
Signal transducer and activation | 8.41 × 10-17 | 44/1184 |
NF-kB | 2.66 × 10-16 | 49/1542 |
Chemokine (CC motif) ligand 2 | 8.63 × 10-16 | 23/272 |
Interleukin 6 | 1.91 × 10-15 | 33/680 |
Toll like receptor | 2.39 × 10-15 | 31/593 |
Immune | 4.25 × 10-15 | 38/957 |
Inflammatory | 4.85 × 10-15 | 41/1133 |
Tumor necrosis factor | 2.14 × 10-14 | 41/1182 |
Interleukin 1 | 2.87 × 10-13 | 31/706 |
Janus kinase | 2.89 × 10-13 | 30/657 |
Molecular functions (GO) | Â | Â |
Cytokine activity | 1.21 × 10-10 | 14/199 |
Receptor binding | 3.74 × 10-9 | 25/917 |
Cytokine receptor binding | 7.90 × 10-9 | 12/187 |
Protein binding | 5.75 × 10-6 | 80/8067 |
Biological processes (GO) | Â | Â |
Immune response | 1.59 × 10-14 | 29/736 |
Immune system process | 3.15 × 10-13 | 33/1094 |
Response to stress | 1.53 × 10-12 | 42/1880 |
Defense response | 2.45 × 10-12 | 26/708 |
Response to stimulus | 2.98 × 10-11 | 58/3713 |