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Table 4 Genes most significantly differentially expressed by bMEC stimulated by LPS for 3 and 6 h compared to unstimulated cells, ordered by functional classes

From: Differential response of bovine mammary epithelial cells to Staphylococcus aureus or Escherichia coli agonists of the innate immune system

Gene symbol Gene description Fold change
3 h 6 h
Transcription and activation pathways   
  NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.60 4.53
  BIRC3 Baculoviral IAP repeat-containing protein 3 3.10 3.19
  ZNFX1 NFX1-type zinc finger-containing protein 1   3.11
  ZNHIT3 Zinc finger HIT domain-containing protein 3 2.48 3.08
  IKBKAP Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 2.52 2.33
  TRIM21 Tripartite motif-containing protein 21 1.61 2.26
  CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.02 1.60
  NFKB2 Nuclear factor of κ light polypeptide gene enhancer in B-cells 2 1.78 1.94
  JAK2 Janus kinase 2 1.90 1.85
  DUSP1 Dual specificity phosphatase 1   1.85
  FOS V-fos   -2.01
  PLK2 Serum-inducible kinase, transcript variant 1,PLK2 -1.50  
Cytokines and chemokines, growth factors   
  CCL5 RANTES 7.10 20.52
  CCL20 Chemokine (C-C motif) ligand 20 19.42 19.37
  CXCL8 Chemokine (C-X-C motif) ligand 8, Interleukin-8 8.53 13.96
  CXCL5 Chemokine (C-X-C motif) ligand 4.75 7.96
  CCL2 Chemokine (C-C motif) ligand 2   6.38
  CXCL2 Chemokine (C-X-C motif) ligand 2   5.06
  CXCL1 Chemokine (C-X-C motif) ligand 1 4.93  
  IL6 Interleukin 6 6.64 4.85
  CXCL3 Chemokine (C-X-C motif) ligand 3 3.15 3.60
  IL1B Interleukin 1, beta 5.01 3.32
  IFNB Interferon beta precursor 4.89 3.25
  TNFSF13B Tumor necrosis factor (ligand) superfamily, member 13 (BAFF) 2.96  
  IL2 Interleukin 2 4.30 2.86
  CCL16 Chemokine (C-C motif) ligand 16 2.60 2.77
  CSF2 Colony stimulating factor 2 (granulocyte-macrophage) 1.69 2.10
  IL23A Interleukin 23, alpha subunit p19   2.06
  CTGF Connective tissue growth factor -1.92  
  TGFB2 Transforming growth factor beta-2 precursor   -1.46
Type I IFN-related genes   
  IFIT3 Interferon-induced protein with tetratricopeptide repeats 3 3.02 7.92
  MX1 Myxovirus (influenza virus) resistance 1 1.84 2.93
  IFIH1 Interferon induced with helicase C domain 1 2.65 4.10
  ISG15 ubiquitin-like modifier 2.46 3.69
  GBP1 Interferon-induced guanylate-binding protein 1 2.17 3.56
  TNFSF10 Tumor necrosis factor ligand superfamily member 10 (TRAIL) 2.02 3.13
  IFI44 Similar to Interferon-induced protein 44   3.23
  OAS1 2′-5′-oligoadenylate synthetase 1 1.61 3.15
  IFI27L1 Interferon alpha-inducible protein 27-like protein 1   2.88
  IRF7 Interferon regulatory factor 7 1.45 2.75
  TRIM21 Tripartite motif-containing protein 21 1.61 2.26
  GVIN1 GTPase, very large interferon inducible 1   2.21
  STAT2 Signal transducer and activator of transcription 2   2.01
  STAT1 Signal transducer and activator of transcription 1   1.96
  IRF2 Interferon regulatory factor 2   1.84
Immune defense response   
  NOS2A Nitric oxide synthase 2A (inducible) 5.57 7.45
  S100A8 Calcium-binding protein A8, calgranulin A 2.87 7.00
  CFB Complement factor B 3.39 5.02
  S100A9 Calcium-binding protein A9, calgranulin B 2.40 4.59
  CD83 Cell surface protein HB15 5.50 3.40
  C2 C2 Complement component 2 1.79 2.64
  ICAM1 Intercellular adhesion molecule 1 2.50  
  LTF Lactotransferrin   2.47
  PLAT Plasminogen activator, tissue type 1.93 2.11
  PLAUR Urokinase plasminogen activator surface receptor 2.11 1.96
  CAMP Cathelicidin antimicrobial peptide   1.89
  TLR4 Toll-like receptor 4 1.62 1.81
  MMP9 Matrix metallopeptidase 9   1.77
  CD74 Major histocompatibility complex, class II invariant chain   1.75
  BNBD10 Beta-defensin 10 1.59 1.67
Stress response   
  SOD2 Superoxide dismutase 2 3.19 5.05
  SGK1 Serum/glucocorticoid regulated kinase 1 1.81 4.79
  PARP14 Poly (ADP-ribose) polymerase family, member 14   2.95
Cell growth and cycle, apoptosis   
  IGFBP3 Insulin-like growth factor binding protein-3 2.38 5.27
  EIF4E Translation initiation factor 4E 2.32 5.20
  CASP4 Caspase-4 Precursor 1.60 3.04
  CASP8 Caspase-8 precursor 1.58 2.29
  IER3 Immediate early response 3 2.09  
  TNFRSF6 TNF receptor superfamily, member 6 (FAS) 1.82 1.86
  CDK2AP1 Cyclin-dependent kinase 2 associated protein 1   -1.66
  EI24 Etoposide-induced protein 2.4 homolog   -1.65