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Table 1 List of genes up- or down-regulated in the chicken cecum after infection with Salmonella Enteritidis arranged according to their maximal fold up- or down-regulation after infection with wild type Salmonella Enteritidis (column max fold SE wt)

From: Chicken innate immune response to oral infection with Salmonella enterica serovar Enteritidis

Gene

Max NI#

Min NI

Max SE

Min SE

Max fold

WT fold

SPI1 fold

     

SE wt$

4 dpi&

4 dpi&

MMP7

0.078 (12)

0.001 (29)

8.98 (5)

0.001 (1)

5952 (10)

1578

35.2

IgG

5.02 (25)

0.006 (2)

36.7 (25)

0.009 (1)

442 (10)

33.2

1.63

IRG1

0.005 (2)

0.001 (11)

0.69 (5)

0.003 (1)

425 (7)

222

4.61

SAA

0.25 (2)

0.018 (9)

15.9 (5)

0.065 (1)

382 (5)

106

5.02

ExFABP

1.06 (18)

0.150 (9)

75.3 (5)

0.369 (1)

366 (5)

56.8

4.80

IL-22

0.005 (12)

0.0004 (10)

0.39 (5)

0.001 (1)

355 (10)

46.9

2.69

TRAP6

0.39 (2)

0.011 (15)

5.76 (5)

0.029 (25)

194 (5)

37.3

2.19

MRP126

0.16 (2)

0.003 (29)

1.96 (5)

0.018 (25)

194 (11)

14.3

2.11

IFNγ

0.001 (18)

0.0001 (11)

0.035 (5)

0.0002 (1)

183 (11)

62.8

1.39

IL1β

0.018 (18)

0.002 (1)

0.74 (5)

0.002 (1)

134 (3)

29.1

1.59

iNOS

0.019 (1)

0.008 (9)

1.99 (7)

0.019 (1)

151 (7)

47.9

2.84

ES1

2.06 (2)

0.055 (29)

39.6 (4)

0.178 (1)

139 (11)

17.4

2.21

LYG2

0.26 (7)

0.015 (22)

5.82 (3)

0.031 (25)

130 (3)

24.5

3.09

IFIT5

0.56 (12)

0.003 (1)

1.28 (3)

0.003 (1)

124 (3)

42.4

2.62

IL-17

0.014 (2)

0.0003 (29)

0.095 (3)

0.001 (22)

120 (11)

6.72

1.12

AVD

2.07 (2)

0.20 (29)

103.1 (5)

0.207 (1)

116 (9)

29.6

3.24

AH221

0.73 (18)

0.12 (1)

23.4 (5)

0.119 (1)

108 (5)

42.9

1.90

serpin B

0.096 (2)

0.002 (29)

0.54 (5)

0.009 (25)

101 (5)

18.4

1.45

TGM4

0.092 (12)

0.005 (6)

0.92 (5)

0.014 (1)

68 (6)

30.4

1.99

IgA

6.04 (18)

0.003 (2)

23.4 (22)

0.005 (3)

49 (3)

16.6

1.86

EPSTI1

0.39 (12)

0.015 (1)

0.74 (4)

0.015 (1)

33 (3)

12.9

1.40

IL-8

0.15 (6)

0.004 (29)

1.08 (4)

0.007 (1)

31 (11)

4.54

1.24

C3

0.092 (2)

0.019 (10)

0.78 (11)

0.044 (1)

29 (10)

9.7

1.53

mucin-2

0.37 (3)

0.018 (9)

0.77 (4)

0.124 (6)

20 (11)

1.01

0.94

PTGDS

1.50 (9)

0.12 (1)

17.8 (5)

0.117 (1)

19 (5)

14.9

1.70

ITGLB2 (CD18)

0.084 (22)

0.031 (3)

0.46 (11)

0.045 (18)

14 (11)

9.40

1.04

HPX

0.19 (7)

0.025 (12)

0.91 (5)

0.071 (25)

13 (5)

5.06

1.10

ASL2

0.46 (2)

0.15 (29)

2.26 (4)

0.289 (1)

11 (10)

3.74

1.17

HCLS1

0.25 (29)

0.088 (5)

1.11 (10)

0.107 (1)

10 (11)

5.41

1.13

TAP1

0.443 (22)

0.087 (3)

2.26 (7)

0.104 (1)

10 (4)

13.7

1.37

STAT1

0.31 (12)

0.059 (9)

1.03 (3)

0.164 (1)

9.2 (9)

8.61

1.25

RSFR

0.96 (8)

0.40 (1)

7.19 (5)

0.397 (1)

9.1 (5)

6.41

1.19

MEG1

0.49 (22)

0.090 (3)

1.80 (5)

0.115 (1)

7.0 (5)

8.22

0.92

STAT3

0.64 (18)

0.37 (3)

1.28 (7)

0.537 (5)

2.2 (3)

2.91

1.00

AQP8

33.4 (22)

14.9 (1)

17.6 (25)

0.290 (5)

97 (5)

18.90

1.80

ADH1B

9.46 (7)

3.42 (2)

4.66 (25)

0.100 (5)

75 (5)

16.23

1.55

FABP1

6.11 (22)

1.98 (11)

8.48 (22)

0.119 (5)

47 (5)

5.49

1.32

RALDH1

18.6 (22)

9.17 (2)

12.6 (1)

0.404 (5)

39 (5)

12.87

1.43

unchar. oxidoreductase

5.84 (12)

0.80 (4)

4.25 (22)

0.192 (5)

28 (5)

7.14

1.26

CALB1

24.2 (1)

8.20 (2)

24.2 (1)

0.785 (5)

19 (5)

13.78

1.88

ALDOB

1.66 (22)

0.32 (2)

0.58 (22)

0.037 (5)

19 (10)

6.71

0.99

SULT1C3

21.9 (4)

7.20 (29)

16.0 (1)

1.081 (5)

18 (5)

8.04

1.86

HPGD

4.62 (7)

1.58 (1)

2.77 (2)

0.396 (5)

10 (7)

8.87

1.29

  1. # Maximal or minimal expression levels observed in the non-infected or Salmonella Enteritidis infected chickens as determined in the time-dependent study; numbers in brackets indicate the day of life when the appropriate value was recorded.
  2. $ Maximal fold upregulation or downregulation and the day when recorded in the time-dependent study. The downregulated genes are at the bottom of the table starting with AQP8.
  3. & Fold up or downregulations 4 days post-infection of chickens with wild-type Salmonella Enteritidis and the SPI1 mutant.